Bertelloni S, Baroncelli G I, Tomasi O, Sorrentino M C, Costa S, Saggese G
Cattedra di Pediatria Preventiva e Sociale, Istituto di Clinica Pediatrica, Università di Pisa, Italia.
Pediatr Med Chir. 1995 Jul-Aug;17(4):353-7.
Sotos syndrome is a rare disorder of statural overgrowth in children. Peculiar facies, pre- and post-natal overgrowth and advanced bone age are the main clinical findings; developmental delay may be present. The Authors report a case of Sotos syndrome followed until adult height and describe the pattern of growth. The girl showed the typical findings of the syndrome together with premature pubarche and premature pubertal development. Since precocious puberty determines an increase of growth during childhood, the Authors suggest that Sotos syndrome should be considered and excluded in girls with premature pubertal development.
索托斯综合征是一种儿童身材过度生长的罕见疾病。特殊面容、出生前后过度生长和骨龄提前是主要临床特征；可能存在发育迟缓。作者报告了一例随访至成年身高的索托斯综合征病例，并描述了其生长模式。该女孩表现出该综合征的典型特征以及阴毛早现和青春期过早发育。由于性早熟会导致儿童期生长加速，作者建议对于青春期过早发育的女孩应考虑并排除索托斯综合征。
