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无细胞百日咳疫苗(Pa)

[Acellular pertussis vaccine (Pa)].

作者信息

Magdzik W

机构信息

Zakład Epidemiologii Państwowego Zakładu Higieny w Warszawie.

出版信息

Przegl Epidemiol. 1995;49(3):325-9.

PMID:7491431
Abstract

Vaccination by whole-cell pertussis vaccine (Pw) since forties years was followed by decreasing of morbidity and especially mortality caused by pertussis. High reactogenicity of this vaccine (Pw) was the reason trials undertaken to search new type of less reactogenic vaccine. Acellular pertussis vaccine (Pa) was found as effective, safe, small reactogenic. It may be especially used as booster doses for older children and even for adults people. Actual pertussis infection among adults are suspected as the source infection for children. Just now in some countries acellular vaccine start to be used for ground vaccination of children. Increasing of morbidity of pertussis was noted in some provinces in Poland in last time. Acellular pertussis vaccine may be introduced as booster dose for 6-7 years old children, if epidemiological situation of pertussis among school-age children would be not satisfied in future.

摘要

自四十年代以来,使用全细胞百日咳疫苗(Pw)进行接种后,百日咳的发病率,尤其是死亡率有所下降。这种疫苗(Pw)的高反应原性促使人们开展试验以寻找新型低反应原性疫苗。无细胞百日咳疫苗(Pa)被发现具有有效性、安全性且反应原性小。它尤其可作为大龄儿童甚至成人的加强剂量使用。成人中的实际百日咳感染被怀疑是儿童的传染源。目前在一些国家,无细胞疫苗开始用于儿童基础免疫接种。最近在波兰的一些省份,百日咳发病率有所上升。如果未来学龄儿童百日咳的流行病学情况不理想,无细胞百日咳疫苗可作为6至7岁儿童的加强剂量引入。

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