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儿童及青少年家族性高胆固醇血症的诊断与治疗

[Diagnosis and treatment of familial hypercholesterolemia in children and adolescents].

作者信息

Ose L, Tonstad S, Vesterhus P, Wefring K W

机构信息

Lipidklinikken, Medisinsk avdeling A, Rikshospitalet, Oslo.

出版信息

Tidsskr Nor Laegeforen. 1995 Nov 20;115(28):3499-503.

PMID:7491603
Abstract

The identification and management of hyperlipidemias in children are currently limited to persons regarded as being at very high risk, such as those with familial hypercholesterolemia. Universal screening of children is not recommended, but it is important to screen the subset of children and adolescents at highest risk, i.e. those with a family history of premature cardiovascular disease or familial hypercholesterolemia. Treatment of children and adolescents with hypercholesterolemia requires a multidisciplinary approach. Cholesterol-lowering medication may be required in addition to dietary therapy in children with a history of premature coronary heart disease among close relatives.

摘要

目前,儿童高脂血症的识别与管理仅限于被视为极高风险的人群,如家族性高胆固醇血症患者。不建议对儿童进行普遍筛查,但对高危儿童及青少年亚组进行筛查很重要,即那些有早发性心血管疾病家族史或家族性高胆固醇血症的儿童及青少年。治疗儿童及青少年高胆固醇血症需要多学科方法。对于有近亲早发性冠心病病史的儿童,除饮食疗法外可能还需要使用降胆固醇药物。

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