Bodega G, Suárez I, Rubio M, Fernández B
Dpto. de Biología Celular y Genética, Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.
Tissue Cell. 1995 Oct;27(5):555-9. doi: 10.1016/s0040-8166(05)80064-3.
The phylogenetic evolution of the expression of type II cytokeratins (CKs) in the spinal cord of different adult vertebrates has been studied using an anti-CK immunohistochemical technique. Type II CK expression was stronger in lower vertebrates, specially anuran amphibians, than in higher vertebrates. No CK expression was found either in reptiles or birds, but a weak expression was demonstrated in mammals. The main neuroectodermal cell implicated in CK expression was the ependymocyte; some CK-positive radial astrocytes were also found in amphibians and fish, but neither CK-positive astrocytes nor neurons were observed in any vertebrate group. The functional significance of CK expression in the vertebrate spinal cord is not known. CKs do not have a consistent pattern of expression amongst vertebrates; however, the most common site is the ependyma.
利用抗细胞角蛋白免疫组织化学技术，研究了不同成年脊椎动物脊髓中II型细胞角蛋白（CKs）表达的系统发育进化。在低等脊椎动物，特别是无尾两栖动物中，II型CK的表达比高等脊椎动物更强。在爬行动物和鸟类中均未发现CK表达，但在哺乳动物中显示出微弱表达。参与CK表达的主要神经外胚层细胞是室管膜细胞；在两栖动物和鱼类中也发现了一些CK阳性的放射状星形胶质细胞，但在任何脊椎动物组中均未观察到CK阳性星形胶质细胞或神经元。CK在脊椎动物脊髓中表达的功能意义尚不清楚。CKs在脊椎动物中没有一致的表达模式；然而，最常见的部位是室管膜。
