Processing and activation of recombinant mouse mastocytoma histidine decarboxylase in the particulate fraction of Sf9 cells by porcine pancreatic elastase.
作者信息
Tanaka S, Fukui T, Yamamoto J, Shima Y, Kume T, Ohgo M, Ichikawa A
机构信息
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
出版信息
Biochim Biophys Acta. 1995 Nov 15;1253(1):9-12. doi: 10.1016/0167-4838(95)00185-w.
PMID:7492605
Abstract
Mature 53 kDa histidine decarboxylase (HDC) peptide is produced from a precursor 74 kDa peptide. The mechanism of specific cleavage by processing enzyme is unknown. Using the recombinant mouse 74 kDa HDC, we found that porcine pancreatic elastase specifically converted the inactive 74 kDa HDC to its active form of 53 kDa HDC.
摘要
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