Tanaka S, Fukui T, Yamamoto J, Shima Y, Kume T, Ohgo M, Ichikawa A
Department of Physiological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Biochim Biophys Acta. 1995 Nov 15;1253(1):9-12. doi: 10.1016/0167-4838(95)00185-w.
Mature 53 kDa histidine decarboxylase (HDC) peptide is produced from a precursor 74 kDa peptide. The mechanism of specific cleavage by processing enzyme is unknown. Using the recombinant mouse 74 kDa HDC, we found that porcine pancreatic elastase specifically converted the inactive 74 kDa HDC to its active form of 53 kDa HDC.
成熟的53 kDa组氨酸脱羧酶（HDC）肽由74 kDa的前体肽产生。加工酶特异性切割的机制尚不清楚。使用重组小鼠74 kDa HDC，我们发现猪胰弹性蛋白酶可将无活性的74 kDa HDC特异性转化为其活性形式的53 kDa HDC。
