二硝基苯急性中毒时尿儿茶酚胺排泄及血糖反应

Urinary catecholamine excretion and blood sugar response during acute poisonings with dinitrobenzenes.

作者信息

Pankow D, Ponsold W

出版信息

Toxicology. 1978 Dec;11(4):377-83. doi: 10.1016/s0300-483x(78)92289-8.

Abstract

Rats were injected intraperitoneally with 0.015 mmol of p-dinitrobenzene/kg, 0.15 mmol of m-dinitrobenzene/kg and 0.45 mmol of o-dinitrobenzene/kg body wt. The dinitrobenzenes induced methaemoglobin concentrations of 86%, 60% and 49%, respectively, as well as increases of urinary catecholamine excretion and blood sugar concentration. Due to hyperglycaemia the glycolysis may be stimulated as mechanism for energy production in methaemoglobin-induced oxygen deficiency and as mechanism for reduction of methaemoglobin, that means as responses favouring survival after poisoning.

摘要

给大鼠腹腔注射对二硝基苯0.015 mmol/kg、间二硝基苯0.15 mmol/kg和邻二硝基苯0.45 mmol/kg体重。二硝基苯分别诱导高铁血红蛋白浓度达到86%、60%和49%，同时尿儿茶酚胺排泄和血糖浓度升高。由于高血糖，糖酵解可能被刺激，作为高铁血红蛋白诱导的缺氧时的能量产生机制以及高铁血红蛋白还原机制，也就是说作为中毒后有利于存活的反应。