Becker W S, Behr T M, Cumme F, Rössler W, Wendler J, Kern P M, Gramatzki M, Kalden J R, Goldenberg D M, Wolf F G
Department of Nuclear Medicine, University of Erlangen-Nuremberg, Germany.
Cancer Res. 1995 Dec 1;55(23 Suppl):5771s-5773s.
The value of 67Ga citrate scanning as a transferrin receptor agent was compared in this study with a 99mTc-labeled anti-CD22 (B-cell) Fab' fragment (LL2) in patients with low- and high-grade B-cell non-Hodgkin's lymphoma (NHL). Thirteen patients with histologically confirmed NHL were examined prospectively with both radiopharmaceuticals within 8 days. The results of immunoscintigraphy were compared with those of 67Ga scanning and the clinical and radiological workup (computed tomography, ultrasound, and magnetic resonance imaging) of the patients. The overall sensitivity of 67Ga citrate and 99mTc-labeled LL2 fragment was each 80% in a total of 43 lesions. Low-grade lymphoma patients had a higher sensitivity in LL2 imaging (82% versus 71%), and high-grade lymphoma patients in 67Ga citrate scanning (100% versus 75%). The target:background ratio in low-grade NHL for LL2 was 1.43 +/- 0.3:1 versus 1.8 +/- 0.5:1 in 67Ga scans; in high-grade NHL, 1.49 +/- 0.35:1 versus 2.2 +/- 0.8:1, respectively. Single-photon emission computed tomography imaging was necessary in 21.7% of the patients 4 h after injection to localize the lesions. In conclusion, the overall sensitivity of 99mTc-labeled LL2 is comparable to 67Ga citrate scanning in patients with B-cell NHL. 99mTc-labeled LL2 antibodies are rapid to use, are safe, and need a shorter imaging time (24 h versus 72 h). Because of these advantages, 99mTc-labeled LL2 may be superior to 67Ga scanning for the staging of lymphoma patients.
本研究比较了枸橼酸镓扫描作为转铁蛋白受体显像剂，与99mTc标记的抗CD22（B细胞）Fab'片段（LL2）在低级别和高级别B细胞非霍奇金淋巴瘤（NHL）患者中的应用价值。13例经组织学确诊的NHL患者在8天内先后接受了这两种放射性药物的前瞻性检查。将免疫闪烁显像的结果与镓67扫描结果以及患者的临床和影像学检查（计算机断层扫描、超声和磁共振成像）结果进行了比较。在总共43个病灶中，枸橼酸镓和99mTc标记的LL2片段的总体敏感性均为80%。低级别淋巴瘤患者在LL2显像中的敏感性更高（82%对71%），而高级别淋巴瘤患者在枸橼酸镓扫描中的敏感性更高（100%对75%）。在低级别NHL中，LL2的靶本比为1.43±0.3:1，而镓67扫描为1.8±0.5:1；在高级别NHL中，分别为1.49±0.35:1和2.2±0.8:1。21.7%的患者在注射后4小时需要进行单光子发射计算机断层扫描成像以定位病灶。总之，在B细胞NHL患者中，99mTc标记的LL2的总体敏感性与枸橼酸镓扫描相当。99mTc标记的LL2抗体使用快速、安全，且成像时间更短（24小时对72小时）。由于这些优势，99mTc标记的LL2在淋巴瘤患者分期方面可能优于镓67扫描。
