Deyst K A, Toole B P
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA 02111, USA.
Brain Res Dev Brain Res. 1995 Aug 28;88(1):122-5. doi: 10.1016/0165-3806(95)00086-s.
The extracellular matrix of brain is largely composed of aggregates formed by assembly of many proteoglycan and link protein molecules along a hyaluronan polymer backbone. Some cell types construct large, highly hydrated, pericellular matrices or 'coats' from these hyaluronan-mediated aggregates. We show here that embryonic glial cells produce such hyaluronan-dependent pericellular matrices in response to addition of serum or basic fibroblast growth factor plus transforming growth factor-beta. It is proposed that such a matrix is a significant component of the extracellular milieu of the brain, especially during morphogenesis within the developing brain, and that basic fibroblast growth factor and transforming growth factor-beta regulate its production.
大脑的细胞外基质主要由许多蛋白聚糖和连接蛋白分子沿着透明质酸聚合物主链组装形成的聚集体组成。一些细胞类型利用这些由透明质酸介导的聚集体构建大型、高度水合的细胞周基质或“包膜”。我们在此表明，胚胎神经胶质细胞在添加血清或碱性成纤维细胞生长因子加转化生长因子-β后会产生这种依赖透明质酸的细胞周基质。有人提出，这样的基质是大脑细胞外环境的重要组成部分，尤其是在发育中大脑的形态发生过程中，并且碱性成纤维细胞生长因子和转化生长因子-β调节其产生。
