Munaim S I, Klagsbrun M, Toole B P
Department of Anatomy and Cellular Biology, Tufts University Health Science Schools, Boston, Massachusetts 02111.
Dev Biol. 1991 Feb;143(2):297-302. doi: 10.1016/0012-1606(91)90080-m.
Basic fibroblast growth factor (FGF) has been shown previously to be present in the chick embryonic limb during early stages of its development, at which time the limb mesodermal cells are proliferating within a hyaluronan-rich extracellular matrix. In this study, basic FGF was found to stimulate hyaluronan synthesis and production of hyaluronan-dependent pericellular coats by mesodermal cells from the chick embryo limb; acidic FGF, platelet-derived growth factor, epidermal growth factor, and retinoic acid either had a much smaller effect than basic FGF or an inhibitory effect. Transforming growth factor-beta stimulated hyaluronan synthesis and coat formation but, unlike basic FGF, this factor also stimulated chondroitin sulfate production by the mesodermal cells.
碱性成纤维细胞生长因子（FGF）先前已被证明在鸡胚肢体发育的早期阶段存在，此时肢体中胚层细胞在富含透明质酸的细胞外基质中增殖。在本研究中，发现碱性FGF可刺激鸡胚肢体中胚层细胞合成透明质酸并产生依赖于透明质酸的细胞周被；酸性FGF、血小板衍生生长因子、表皮生长因子和视黄酸的作用要么比碱性FGF小得多，要么具有抑制作用。转化生长因子-β刺激透明质酸合成和被膜形成，但与碱性FGF不同的是，该因子还刺激中胚层细胞产生硫酸软骨素。
