Smeenk R J
Dept of Autoimmune Diseases, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
Clin Rheumatol. 1995 Jul;14 Suppl 1:11-6. doi: 10.1007/BF03342632.
Sjögren's syndrome is characterized serologically by the presence of autoantibodies against Ro/SS-A and La/SS-B. The mechanisms by which these autoantibodies arise is not clear at this moment. B cells capable of producing antibodies to Ro/SS-A and La/SS-B seem to be present in every individual; whether or not an individual indeed makes these antibodies is governed by T cells. Recent experiments from us and from others indicate that T cell tolerance towards Ro/SS-A and La/SS-B can be broken by immunization of normal mice with recombinant human Ro/SS-A or La/SS-B. The specificity of the T cells directing the anti-Ro/SS-A and anti-La/SS-B autoantibody response in these animals has not yet been elucidated. T cells may either be directed against foreign epitopes present on the human immunogen or they may be truly autoreactive. In patients with Sjögren's syndrome, a comparable immunization route might encompass product of viral origin directing the T cell response via RNA/protein complexes. Putative candidates comprise viruses that make use of RNAse polymerase-III, such as Epstein Barr virus, adenovirus, vesicular stomatitis virus en rabies virus.
干燥综合征在血清学上的特征是存在针对Ro/SS-A和La/SS-B的自身抗体。目前尚不清楚这些自身抗体产生的机制。每个个体似乎都存在能够产生针对Ro/SS-A和La/SS-B抗体的B细胞；个体是否真的产生这些抗体则由T细胞决定。我们和其他人最近的实验表明，用重组人Ro/SS-A或La/SS-B免疫正常小鼠可打破T细胞对Ro/SS-A和La/SS-B的耐受性。在这些动物中，指导抗Ro/SS-A和抗La/SS-B自身抗体反应的T细胞特异性尚未阐明。T细胞可能针对人类免疫原上存在的外来表位，也可能是真正的自身反应性。在干燥综合征患者中，类似的免疫途径可能包括病毒来源的产物通过RNA/蛋白质复合物指导T细胞反应。假定的候选病毒包括利用RNA聚合酶III的病毒，如爱泼斯坦-巴尔病毒、腺病毒、水疱性口炎病毒和狂犬病病毒。
