Abbott W G, Geursen A, Peake J S, Simpson I J, Skinner M A, Tan P L
Department of Molecular Medicine, School of Medicine, University of Auckland, New Zealand.
Immunol Cell Biol. 1995 Aug;73(4):369-71. doi: 10.1038/icb.1995.56.
A population-based linkage disequilibrium study was conducted to search for associations between alleles in T cell receptor alpha and beta chain polymorphic loci and susceptibility to rheumatic fever. The allele frequencies of four T cell receptor locus restriction fragment length polymorphisms were measured in 47 European and 51 Maori subjects with a history of rheumatic fever. These allele frequencies were compared to the allele frequencies in three or four independently recruited, race-matched control groups totalling 125 Europeans and 117 Maoris with no history of rheumatic fever. The polymorphisms studied were (locus/enzyme/probe) C alpha/Taq1/Y14, V alpha/Taq1/Y14, V beta 7/BAMHI/V beta 7.4 and V beta 8/BAMHI/V beta 8.1. There was no evidence for linkage disequilibrium between rheumatic fever and these Tcr alleles in either the Maori or European subjects.
开展了一项基于人群的连锁不平衡研究，以寻找T细胞受体α和β链多态性位点的等位基因与风湿热易感性之间的关联。在47名有风湿热病史的欧洲人和51名毛利人受试者中，测量了四个T细胞受体基因座限制性片段长度多态性的等位基因频率。将这些等位基因频率与三个或四个独立招募的、种族匹配的对照组（共计125名无风湿热病史的欧洲人和117名无风湿热病史的毛利人）的等位基因频率进行比较。所研究的多态性为（基因座/酶/探针）Cα/Taq1/Y14、Vα/Taq1/Y14、Vβ7/BAMHI/Vβ7.4和Vβ8/BAMHI/Vβ8.1。在毛利人或欧洲受试者中，均没有证据表明风湿热与这些Tcr等位基因之间存在连锁不平衡。
