Chomel B B, Abbott R C, Kasten R W, Floyd-Hawkins K A, Kass P H, Glaser C A, Pedersen N C, Koehler J E
Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis 95616, USA.
J Clin Microbiol. 1995 Sep;33(9):2445-50. doi: 10.1128/jcm.33.9.2445-2450.1995.
The isolation of Bartonella henselae, the agent of cat scratch disease, from the blood of naturally infected domestic cats and the demonstration that cats remain bacteremic for several months suggest that cats play a major role as a reservoir for this bacterium. A convenience sample of 205 cats from northern California was selected between 1992 and 1994 to evaluate the B. henselae antibody and bacteremia prevalences and to determine the risk factors and associations between bacteremia and antibody titers. B. henselae was isolated from the blood of 81 cats (39.5%). Forty-two (52%) of these bacteremic cats were found to be infected with > or = 1,000 CFU/ml of blood. Impounded or former stray cats were 2.86 (95% confidence interval [CI] = 1.94, 4.22) times more likely to be bacteremic than the pet cats. Young cats ( < 1 year old) were more likely than adult cats to be bacteremic (relative risk = 1.64; (95% CI = 1.19, 2.28). Bacteremic cats were more likely than nonbacteremic cats to be infested with fleas (relative risk = 1.64; 95% CI = 1.38, 1.96). No association between B. henselae infection and feline immunodeficiency virus antibody prevalence was observed. Eighty-one percent of the cats (166 of 205) tested positive for B. henselae antibodies, and titers were higher in bacteremic than in nonbacteremic cats. Multiple logistic regression analysis indicated that younger age and seropositivity for B. henselae antibodies were associated with bacteremia. Serological screening for Bartonella antibodies may not be useful for the identification of bacteremic cats (positive predictive value = 46.4%), but the lack of antibodies to B. henselae was highly predictive of the absence of bacteremia (negative predictive value = 89.7%). Seronegative cats may be more appropriate pets for immunocompromised individuals who are at increased risk for developing severe B. henselae disease.
从自然感染的家猫血液中分离出猫抓病病原体汉赛巴尔通体，且证明猫可保持菌血症数月之久，这表明猫作为该细菌的宿主起着主要作用。1992年至1994年间，从北加利福尼亚选取了205只猫作为便利样本，以评估汉赛巴尔通体抗体和菌血症患病率，并确定菌血症的危险因素以及菌血症与抗体滴度之间的关联。从81只猫（39.5%）的血液中分离出了汉赛巴尔通体。在这些菌血症猫中，有42只（52%）被发现血液中感染菌量≥1000 CFU/ml。被收容的猫或曾经的流浪猫菌血症发生几率是宠物猫的2.86倍（95%置信区间[CI]=1.94, 4.22）。幼猫（<1岁）比成年猫更易发生菌血症（相对风险=1.64；95%CI=1.19, 2.28）。菌血症猫比非菌血症猫更易感染跳蚤（相对风险=1.64；95%CI=1.38, 1.96）。未观察到汉赛巴尔通体感染与猫免疫缺陷病毒抗体患病率之间存在关联。81%的猫（205只中的166只）汉赛巴尔通体抗体检测呈阳性，菌血症猫的抗体滴度高于非菌血症猫。多因素逻辑回归分析表明，年龄较小和汉赛巴尔通体抗体血清学阳性与菌血症相关。汉赛巴尔通体抗体的血清学筛查可能对识别菌血症猫无用（阳性预测值=46.4%），但缺乏汉赛巴尔通体抗体可高度预测无菌血症（阴性预测值=89.7%）。血清学阴性的猫对于发生严重汉赛巴尔通体病风险增加的免疫功能低下个体可能是更合适的宠物。
