Ferreira R C, Lamberts M, Moreira J B, Campos M S
Department of Ophthalmology, Paulista School of Medicine, Sao Paulo, Brazil.
J Pediatr Ophthalmol Strabismus. 1995 Jul-Aug;32(4):239-42. doi: 10.3928/0191-3913-19950701-10.
The efficacy of hydroxypropylmethylcellulose and sodium hyaluronate as adjuncts during adjustable strabismus surgery was evaluated experimentally. Fifteen randomized NZA rabbits underwent a bilateral 4-mm recession of the superior rectus followed by a 0.05 mL injection of submuscular hydroxypropylmethylcellulose 2% (HPMC) in one eye and sodium hyaluronate 1% (Healon) in the other eye. Five additional rabbits (10 eyes), used as controls, underwent the same procedure, but no viscoelastic was injected after surgery. The force needed to move the muscle 4 mm toward its original insertion was measured immediately and 24 hours after the operation, using a force gauge. The force needed to adjust the muscles increased 326.0%, 98%, and 124.7%, respectively in the control, Healon and HPMC groups (p < 0.001). No significant difference was found between the two viscoelastic substances. Histologic evaluation of the operation sites disclosed similar inflammation in both controls and viscoelastic groups (p = .5960).
对羟丙基甲基纤维素和透明质酸钠在可调节性斜视手术中作为辅助剂的疗效进行了实验评估。15只随机分组的新西兰白兔接受双侧上直肌4毫米后徙术，然后在一只眼睛中注射0.05毫升2%的羟丙基甲基纤维素（HPMC）肌下注射剂，在另一只眼睛中注射1%的透明质酸钠（Healon）。另外5只兔子（10只眼睛）作为对照，接受相同的手术，但术后不注射粘弹剂。使用测力计在术后立即和术后24小时测量将肌肉向其原始附着点移动4毫米所需的力。对照组、Healon组和HPMC组中调整肌肉所需的力分别增加了326.0%、98%和124.7%（p<0.001）。两种粘弹剂之间未发现显著差异。手术部位的组织学评估显示，对照组和粘弹剂组的炎症相似（p = 0.5960）。
