• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

人巨细胞病毒IE1和IE2蛋白可阻止细胞凋亡。

Human cytomegalovirus IE1 and IE2 proteins block apoptosis.

作者信息

Zhu H, Shen Y, Shenk T

机构信息

Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, New Jersey 08544-1014, USA.

出版信息

J Virol. 1995 Dec;69(12):7960-70. doi: 10.1128/JVI.69.12.7960-7970.1995.

DOI:10.1128/JVI.69.12.7960-7970.1995
PMID:7494309
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189741/
Abstract

Human cytomegalovirus-infected fibroblasts are resistant to the induction of apoptosis by superinfection with a mutant adenovirus unable to produce the viral E1B 19-kDa protein that normally causes an E1A protein-mediated apoptotic response. Two cytomegalovirus gene products that block apoptosis were identified. The IE1 and IE2 proteins each inhibit the induction of apoptosis by tumor necrosis factor alpha or by the E1B 19-kDa-protein-deficient adenovirus but not by irradiation with UV light. Our results suggest a new physiological role for the IE1 and IE2 proteins in the human cytomegalovirus replication cycle.

摘要

人巨细胞病毒感染的成纤维细胞对一种突变腺病毒的超感染诱导凋亡具有抗性，该突变腺病毒无法产生通常会引起E1A蛋白介导的凋亡反应的病毒E1B 19-kDa蛋白。鉴定出了两种阻止凋亡的巨细胞病毒基因产物。IE1和IE2蛋白各自抑制肿瘤坏死因子α或E1B 19-kDa蛋白缺陷型腺病毒诱导的凋亡，但不抑制紫外线照射诱导的凋亡。我们的结果提示了IE1和IE2蛋白在人巨细胞病毒复制周期中的一种新的生理作用。

相似文献

1
Human cytomegalovirus IE1 and IE2 proteins block apoptosis.人巨细胞病毒IE1和IE2蛋白可阻止细胞凋亡。
J Virol. 1995 Dec;69(12):7960-70. doi: 10.1128/JVI.69.12.7960-7970.1995.
2
The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells.人巨细胞病毒的主要立即早期蛋白IE1和IE2在感染的允许细胞中很早的时候就与早幼粒细胞白血病（PML）相关核体共定位并使其破坏。
J Virol. 1997 Jun;71(6):4599-613. doi: 10.1128/JVI.71.6.4599-4613.1997.
3
Disruption of PML-associated nuclear bodies by IE1 correlates with efficient early stages of viral gene expression and DNA replication in human cytomegalovirus infection.在人巨细胞病毒感染中，IE1对PML相关核体的破坏与病毒基因表达及DNA复制的早期高效阶段相关。
Virology. 2000 Aug 15;274(1):39-55. doi: 10.1006/viro.2000.0448.
4
Human cytomegalovirus late protein encoded by ie2: a trans-activator as well as a repressor of gene expression.由ie2编码的人巨细胞病毒晚期蛋白：一种基因表达的反式激活因子及阻遏物。
J Gen Virol. 1994 Sep;75 ( Pt 9):2337-48. doi: 10.1099/0022-1317-75-9-2337.
5
The human cytomegalovirus IE2 and UL112-113 proteins accumulate in viral DNA replication compartments that initiate from the periphery of promyelocytic leukemia protein-associated nuclear bodies (PODs or ND10).人类巨细胞病毒IE2蛋白和UL112 - 113蛋白在从早幼粒细胞白血病蛋白相关核体（PODs或ND10）周边起始的病毒DNA复制区室中积累。
J Virol. 1999 Dec;73(12):10458-71. doi: 10.1128/JVI.73.12.10458-10471.1999.
6
Human cytomegalovirus immediate-early gene 2 protein interacts with itself and with several novel cellular proteins.人巨细胞病毒立即早期基因2蛋白可与自身及几种新的细胞蛋白相互作用。
J Virol. 1993 Aug;67(8):4981-91. doi: 10.1128/JVI.67.8.4981-4991.1993.
7
Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins.人巨细胞病毒早期启动子被即刻早期基因IE2的基因产物反式激活以及被IE1增强：病毒蛋白的突变分析
J Virol. 1990 Apr;64(4):1498-506. doi: 10.1128/JVI.64.4.1498-1506.1990.
8
Effective inhibition of human cytomegalovirus gene expression and replication by a ribozyme derived from the catalytic RNA subunit of RNase P from Escherichia coli.源自大肠杆菌核糖核酸酶P催化RNA亚基的核酶对人巨细胞病毒基因表达和复制的有效抑制作用
Proc Natl Acad Sci U S A. 2000 May 23;97(11):5812-7. doi: 10.1073/pnas.100101797.
9
TAR and Sp1-independent transactivation of HIV long terminal repeat by the Tat protein in the presence of human cytomegalovirus IE1/IE2.在人巨细胞病毒IE1/IE2存在的情况下，Tat蛋白对HIV长末端重复序列的TAR和Sp1非依赖性反式激活。
AIDS. 1997 Mar;11(3):297-303. doi: 10.1097/00002030-199703110-00006.
10
Effects of human cytomegalovirus immediate-early proteins on p53-mediated apoptosis in coronary artery smooth muscle cells.人巨细胞病毒立即早期蛋白对冠状动脉平滑肌细胞中p53介导的细胞凋亡的影响。
Circulation. 1999 Apr 6;99(13):1656-9. doi: 10.1161/01.cir.99.13.1656.

引用本文的文献

1
Cellular antibody affinity-based CRISPR Screening identifies JUNB as a broadly acting anti-viral factor.基于细胞抗体亲和力的CRISPR筛选鉴定出JUNB作为一种广泛作用的抗病毒因子。
bioRxiv. 2025 Jun 13:2025.06.12.659131. doi: 10.1101/2025.06.12.659131.
2
Beyond hearing loss: exploring neurological and neurodevelopmental sequelae in asymptomatic congenital cytomegalovirus infection.听力损失之外：探索无症状先天性巨细胞病毒感染中的神经学和神经发育后遗症。
Pediatr Res. 2025 Jul 8. doi: 10.1038/s41390-025-04232-5.
3
Congenital CMV infection and central nervous system involvement: mechanisms, treatment, and long-term outcomes.先天性巨细胞病毒感染与中枢神经系统受累：机制、治疗及长期预后
Eur J Pediatr. 2025 May 31;184(6):381. doi: 10.1007/s00431-025-06215-4.
4
RNA-targeted proteomics identifies YBX1 as critical for efficient HCMV mRNA translation.RNA靶向蛋白质组学确定YBX1对人巨细胞病毒mRNA的有效翻译至关重要。
Proc Natl Acad Sci U S A. 2025 Mar 11;122(10):e2421155122. doi: 10.1073/pnas.2421155122. Epub 2025 Mar 4.
5
Molecular Insights into HR-HPV and HCMV Co-Presence in Cervical Cancer Development.宫颈癌发生过程中高危型人乳头瘤病毒（HR-HPV）与巨细胞病毒（HCMV）共同存在的分子机制洞察
Cancers (Basel). 2025 Feb 8;17(4):582. doi: 10.3390/cancers17040582.
6
Effect of host telomerase inhibition on human cytomegalovirus.宿主端粒酶抑制对人巨细胞病毒的影响。
J Virol. 2025 Mar 18;99(3):e0157824. doi: 10.1128/jvi.01578-24. Epub 2025 Feb 5.
7
RAF1 promotes successful human cytomegalovirus replication and is regulated by AMPK-mediated phosphorylation during infection.RAF1促进人巨细胞病毒的成功复制，并在感染过程中受到AMPK介导的磷酸化作用的调控。
J Virol. 2025 Mar 18;99(3):e0186624. doi: 10.1128/jvi.01866-24. Epub 2025 Feb 4.
8
Infection-induced lysine lactylation enables herpesvirus immune evasion.感染诱导的赖氨酸乳酰化使疱疹病毒能够逃避免疫。
Sci Adv. 2025 Jan 10;11(2):eads6215. doi: 10.1126/sciadv.ads6215. Epub 2025 Jan 8.
9
Protein phosphatase 1 suppresses PKR/EIF2α signaling during human cytomegalovirus infection.蛋白磷酸酶 1 在人巨细胞病毒感染期间抑制 PKR/EIF2α 信号通路。
J Virol. 2024 Nov 19;98(11):e0059024. doi: 10.1128/jvi.00590-24. Epub 2024 Oct 29.
10
The Pentamer glycoprotein complex inhibits viral Immediate Early transcription during Human Cytomegalovirus infections.五聚体糖蛋白复合物在人类巨细胞病毒感染过程中抑制病毒即刻早期转录。
Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2408078121. doi: 10.1073/pnas.2408078121. Epub 2024 Sep 18.

本文引用的文献

1
Stimulation of cellular DNA synthesis by human cytomegalovirus.人巨细胞病毒对细胞DNA合成的刺激作用。
J Virol. 1974 Feb;13(2):353-62. doi: 10.1128/JVI.13.2.353-362.1974.
2
Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase and nick translation assays.通过原位末端脱氧核苷酸转移酶和缺口平移分析检测单个凋亡细胞中的DNA链断裂。
Cancer Res. 1993 Apr 15;53(8):1945-51.
3
In vivo and in vitro analysis of transcriptional activation mediated by the human cytomegalovirus major immediate-early proteins.人巨细胞病毒主要立即早期蛋白介导的转录激活的体内和体外分析
Mol Cell Biol. 1993 Feb;13(2):1238-50. doi: 10.1128/mcb.13.2.1238-1250.1993.
4
Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.爱泼斯坦-巴尔病毒编码的BHRF1蛋白，即Bcl-2的病毒同源物，可保护人类B细胞免于程序性细胞死亡。
Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8479-83. doi: 10.1073/pnas.90.18.8479.
5
An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstein-Barr virus gene BHRF1.一种与原癌基因bcl-2及爱泼斯坦-巴尔病毒基因BHRF1具有相似性的非洲猪瘟病毒基因。
J Virol. 1993 Jul;67(7):4391-4. doi: 10.1128/JVI.67.7.4391-4394.1993.
6
Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis.腺病毒5 E1A可诱导p53肿瘤抑制因子的稳定，并伴随细胞凋亡。
Genes Dev. 1993 Apr;7(4):535-45. doi: 10.1101/gad.7.4.535.
7
Bcl-2 blocks apoptosis in cells lacking mitochondrial DNA.Bcl-2可阻止线粒体DNA缺失细胞中的细胞凋亡。
Nature. 1993 Jan 28;361(6410):365-9. doi: 10.1038/361365a0.
8
An in vitro system for human cytomegalovirus immediate early 2 protein (IE2)-mediated site-dependent repression of transcription and direct binding of IE2 to the major immediate early promoter.一种用于人巨细胞病毒立即早期2蛋白（IE2）介导的位点依赖性转录抑制以及IE2与主要立即早期启动子直接结合的体外系统。
Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):707-11. doi: 10.1073/pnas.90.2.707.
9
The 86-kilodalton IE-2 protein of human cytomegalovirus is a sequence-specific DNA-binding protein that interacts directly with the negative autoregulatory response element located near the cap site of the IE-1/2 enhancer-promoter.人巨细胞病毒的86千道尔顿IE-2蛋白是一种序列特异性DNA结合蛋白，它直接与位于IE-1/2增强子-启动子帽位点附近的负性自身调节反应元件相互作用。
J Virol. 1993 Jan;67(1):323-31. doi: 10.1128/JVI.67.1.323-331.1993.
10
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.Bcl-2在体内与一个保守的同源物Bax形成异二聚体，后者会加速程序性细胞死亡。
Cell. 1993 Aug 27;74(4):609-19. doi: 10.1016/0092-8674(93)90509-o.