Haruno A, Hashimoto K
Department of Pharmacology, Yamanashi Medical University, Japan.
Jpn J Pharmacol. 1995 May;68(1):95-102. doi: 10.1254/jjp.68.95.
Antiarrhythmic effects of bisaramil were examined by using new in vivo triggered arrhythmia models, and they were compared with those of other antiarrhythmic drugs. Bisaramil (3-10 micrograms, i.c.) suppressed triggered ventricular arrhythmias that were produced during pauses between trains of rapid ventricular stimulation (cycle length: 250 msec, train number: 15) in anesthetized open-chest dog hearts administered with subtoxic doses of digitalis or adrenaline to the anterior descending coronary artery. The potencies of bisaramil, disopyramide, lidocaine and flecainide suppressing digitalis-induced triggered ventricular arrhythmias were similar to those suppressing adrenaline-induced ones. The potency of verapamil for suppressing digitalis-induced triggered ventricular arrhythmias were weaker than that for suppressing the adrenaline-induced ones. Bisaramil was the most effective among the antiarrhythmic drugs used in the present experiment. Since bisaramil has been reported to be effective in suppressing other canine automatic ventricular arrhythmias, and the triggered ventricular arrhythmias occur in clinical situations, bisaramil may become a useful drug for the treatment of clinical arrhythmias.
通过使用新的体内触发心律失常模型研究了比沙米的抗心律失常作用，并将其与其他抗心律失常药物的作用进行了比较。比沙米（3 - 10微克，静脉内注射）抑制了在对麻醉的开胸犬心脏进行快速心室刺激（周期长度：250毫秒，刺激串数：15）的串之间的间歇期产生的触发室性心律失常，这些犬心脏向前降支冠状动脉给予亚中毒剂量的洋地黄或肾上腺素。比沙米、丙吡胺、利多卡因和氟卡尼抑制洋地黄诱导的触发室性心律失常的效力与抑制肾上腺素诱导的触发室性心律失常的效力相似。维拉帕米抑制洋地黄诱导的触发室性心律失常的效力弱于抑制肾上腺素诱导的触发室性心律失常的效力。比沙米在本实验中使用的抗心律失常药物中最有效。由于据报道比沙米在抑制其他犬类自动性室性心律失常方面有效，并且触发室性心律失常在临床情况下会发生，比沙米可能成为治疗临床心律失常的有用药物。
