5-苄基-5-乙基巴比妥酸螺环类似物的合成与药理评价 - Suppr

Suppr

超能文献

Synthesis and pharmacological evaluation of spiro-analogues of 5-benzyl-5-ethyl barbituric acid.

作者信息

King S B, Stratford E S, Craig C R, Fifer E K

机构信息

Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, Morgantown 26505, USA.

出版信息

Pharm Res. 1995 Aug;12(8):1240-3. doi: 10.1023/a:1016236615559.

DOI:10.1023/a:1016236615559

PMID:7494841

Abstract

摘要

相似文献

Synthesis and pharmacological evaluation of spiro-analogues of 5-benzyl-5-ethyl barbituric acid.5-苄基-5-乙基巴比妥酸螺环类似物的合成与药理评价

Pharm Res. 1995 Aug;12(8):1240-3. doi: 10.1023/a:1016236615559.

Anticonvulsants. 4. Metharbital and phenobarbital derivatives.

J Med Chem. 1973 Dec;16(12):1378-81. doi: 10.1021/jm00270a013.

Synthesis and anticonvulsant properties of a series of N-substituted 2-aza-spiro[4.5]decane-1,3-diones and 8-phenyl-2-aza-spiro[4.5]decane-1,3-diones.一系列N-取代的2-氮杂螺[4.5]癸烷-1,3-二酮和8-苯基-2-氮杂螺[4.5]癸烷-1,3-二酮的合成及抗惊厥特性

Acta Pol Pharm. 2004 Nov-Dec;61(6):467-72.

Synthesis and evaluation of 3-[(2,4-dioxo-1,3,8-triazaspiro[4.6]undec-3-yl)methyl]benzonitrile derivatives as potential anticonvulsants.合成及评价 3-[(2,4-二氧代-1,3,8-三氮杂螺[4.6]十一-3-基)甲基]苯甲腈衍生物作为潜在的抗惊厥药物。

Arch Pharm (Weinheim). 2013 Mar;346(3):200-9. doi: 10.1002/ardp.201200400. Epub 2013 Jan 21.

Design, synthesis, and anticonvulsant activity of new N-Mannich bases derived from spirosuccinimides and spirohydantoins.新型 N-曼尼希碱类衍生物的设计、合成及抗惊厥活性研究，此类衍生物是由琥戊二酸亚胺和海因衍生而来。

Bioorg Med Chem. 2010 Aug 15;18(16):6134-42. doi: 10.1016/j.bmc.2010.06.064. Epub 2010 Jun 30.

Spiro[4.5] and spiro[4.6] carboxylic acids: cyclic analogues of valproic acid. Synthesis and anticonvulsant evaluation.

J Med Chem. 1985 Apr;28(4):413-7. doi: 10.1021/jm00382a004.

Synthesis and anticonvulsant activity of N-3-arylamide substituted 5,5-cyclopropanespirohydantoin derivatives.N-3-芳酰胺取代的 5,5-环丙烷螺[二氢嘧啶-2,4-二酮]衍生物的合成及抗惊厥活性。

Eur J Med Chem. 2010 Dec;45(12):5870-7. doi: 10.1016/j.ejmech.2010.09.052. Epub 2010 Oct 1.

Synthesis and anticonvulsant activity of 1-(8-(benzyloxy)quinolin-2-yl)-6-substituted-4,6-diazaspiro[2,4]heptane-5,7-diones.1-(8-(苯甲氧基)喹啉-2-基)-6-取代-4,6-二氮杂螺[2.4]庚烷-5,7-二酮的合成及抗惊厥活性。

Eur J Med Chem. 2012 Feb;48:338-46. doi: 10.1016/j.ejmech.2011.12.037. Epub 2011 Dec 29.

Synthesis, physicochemical and anticonvulsant properties of N-benzyl and N-aminophenyl derivatives of 2-azaspiro[4.4]nonane and [4.5]decane-1,3-dione. Part I.2-氮杂螺[4.4]壬烷和[4.4.5]癸烷-1,3-二酮的N-苄基和N-氨基苯基衍生物的合成、物理化学性质及抗惊厥特性。第一部分。

Farmaco. 2005 Jun-Jul;60(6-7):529-39. doi: 10.1016/j.farmac.2005.05.006.

Benzothiazole incorporated barbituric acid derivatives: synthesis and anticonvulsant screening.含苯并噻唑的巴比妥酸衍生物：合成与抗惊厥活性筛选

Arch Pharm (Weinheim). 2009 Aug;342(8):462-8. doi: 10.1002/ardp.200900002.

引用本文的文献

Biological Evaluation of 3-Azaspiro[Bicyclo[3.1.0]Hexane-2,5'-Pyrimidines] as Potential Antitumor Agents.3-氮杂螺[双环[3.1.0]己烷-2,5'-嘧啶]类化合物的抗肿瘤活性评价。

Int J Mol Sci. 2022 Sep 15;23(18):10759. doi: 10.3390/ijms231810759.

Deacylation-Aided C─H Alkylative Annulation through C─C Cleavage of Unstrained Ketones.通过无张力酮的C-C裂解实现脱酰基辅助的C-H烷基化环化反应

Nat Catal. 2021 Aug;4(8):703-710. doi: 10.1038/s41929-021-00661-7. Epub 2021 Aug 2.

All-Carbon [3+3] Oxidative Annulations of 1,3-Enynes by Rhodium(III)-Catalyzed C-H Functionalization and 1,4-Migration.铑（III）催化的C-H官能化和1,4-迁移实现1,3-烯炔的全碳[3+3]氧化环化反应

Angew Chem Int Ed Engl. 2015 Aug 17;54(34):9958-62. doi: 10.1002/anie.201503978. Epub 2015 Jul 15.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型，支持多种主流文档格式。

立即体验