Bobrov V A, Kolomiets V V
Ter Arkh. 1995;67(9):42-5.
Enhanced and diminished calcemia following administration of parathormone and calcitonin in hypertensive patients, respectively, were found not to differ from relevant values in healthy subjects. Calciuretic effect of parathormone results from its action on the bone and renal calcium transport. Quantitatively, the effects on the bone and renal calcium transport. Quantitatively, the effects on the bone presenting as elevated calcemia and calcium filtration capacity, its excreted fraction and renal excretion prevail, being less pronounced in hypertensive patients. A direct renal effect of parathyroid hormone indicated by stimulation of calcium tubular reabsorption is weaker in hypertensive subjects. Calcitonin administration inhibits tubular calcium reabsorption in the less degree in hypertensive subjects. The disorders in calciuretic function of the kidney in hypertension are secondary to reduced kidney sensitivity to the action of calcium regulating hormones.
分别给高血压患者注射甲状旁腺激素和降钙素后，血钙升高和降低的情况与健康受试者的相关数值并无差异。甲状旁腺激素的利钙作用源于其对骨骼和肾脏钙转运的作用。从数量上看，对骨骼和肾脏钙转运的影响。从数量上看，对骨骼的影响表现为血钙升高和钙滤过能力增强，其排泄分数和肾脏排泄占主导，在高血压患者中不太明显。甲状旁腺激素刺激肾小管对钙的重吸收所表明的直接肾脏作用在高血压患者中较弱。降钙素给药对高血压患者肾小管钙重吸收的抑制程度较小。高血压患者肾脏利钙功能的紊乱继发于肾脏对钙调节激素作用的敏感性降低。
