Stout L, Gerspach J M, Levy S M, Yun S K, Lad P M, Leach G E, Zimmern P E
Department of Urology, Kaiser Permanente Medical Center, Los Angeles, California, USA.
Urology. 1995 Nov;46(5):653-6. doi: 10.1016/S0090-4295(99)80295-7.
Dimethyl sulfoxide (DMSO), an agent that provides symptomatic relief in patients with interstitial cystitis (IC) works via an unknown mechanism. We investigated whether DMSO acts as a chemical stimulant of mast cell degranulation.
A radioimmunoassay (RIA) specific for histamine was used to test this hypothesis. Twelve women with strictly diagnosed IC were treated with intravesical instillations of DMSO. Treatments were repeated at varying intervals, and each patient received three to six treatments. Urine histamine levels were measured before and after each intravesical instillation of DMSO. Dilutional effects of DMSO were corrected for by conversion of urine histamine concentration to urine histamine:creatinine ratio.
The RIA was unaffected by the addition of DMSO to urine. No consistent change in the urine histamine:creatinine ratio following DMSO instillation was found. Trend analysis revealed no trend in the histamine:creatinine ratio with time.
The relief of symptoms reported in 50% to 77% of patients treated with intravesical DMSO is not related to detectable mast cell release of histamine. Other mechanisms of action must be investigated to explain the beneficial effect of this agent.
二甲基亚砜（DMSO）可缓解间质性膀胱炎（IC）患者的症状，但其作用机制尚不清楚。我们研究了DMSO是否作为肥大细胞脱颗粒的化学刺激物。
使用一种针对组胺的放射免疫分析（RIA）来检验这一假设。对12名严格诊断为IC的女性患者进行膀胱内灌注DMSO治疗。治疗以不同间隔重复进行，每位患者接受三至六次治疗。在每次膀胱内灌注DMSO前后测量尿组胺水平。通过将尿组胺浓度转换为尿组胺：肌酐比值来校正DMSO的稀释效应。
向尿液中添加DMSO对RIA无影响。灌注DMSO后，尿组胺：肌酐比值未发现一致变化。趋势分析显示组胺：肌酐比值随时间无趋势变化。
膀胱内灌注DMSO治疗的患者中，有50%至77%报告症状缓解，这与可检测到的肥大细胞释放组胺无关。必须研究其他作用机制来解释该药物的有益效果。
