Oyeyinka G O, Aiyedun B A, Erasmus R T, Adewoye H O, Adetoro O O, Adedoyin M A
Department of Chemical Pathology, Faculty of Health Sciences, University of Ilorin, Nigeria.
Afr J Med Med Sci. 1995 Mar;24(1):9-16.
The levels of complement components C3 and C4 were determined in EDTA (ethylene-diamine-tetra-acetic acid) plasma of 106 apparently healthy people aged 11-50 years, and in 23 paired maternal and cord plasma in Ilorin. The immunoglobulins G,A and M concentrations of these paired samples were also assayed. Furthermore, serum IgG, IgA and IgM levels were quantitated in 501 apparently healthy residents of Ilorin (1-84 years old, n = 313) and its suburban community, Shao (11-80 years old, n = 188). Generally, there were no significant sex-related differences in C3 and C4 values, but these values increased steadily with age. C3 and C4 levels in cord plasma were high, representing 73% and 88% of adult levels respectively. Maternal levels of these complement components were higher (P < 0.02) than values obtained in non-pregnant females of comparable age. Immunoglobulin G values obtained for maternal and cord samples compare well with figures reported previously from other centres in Nigeria. Only 1 of 23 IgA and 2 of 23 IgM samples showed detectable values of these immunoglobulins in cord blood. The mean concentrations of immunoglobulins obtained were similar for IgG and lower for IgA and IgM in Ilorin, but higher for IgG and lower for IgA and IgM in Shao, when compared with data reported from Enugu and Zaria--both in Nigeria. Shao showed significantly higher mean level of IgG but similar levels of IgA and IgM to values obtained in Ilorin. Generally, IgG and IgA concentrations rose gradually up to age group 31-40 and 41-50 years respectively; and then declined. (ABSTRACT TRUNCATED AT 250 WORDS)
在伊洛林，对106名年龄在11至50岁的表面健康人群的乙二胺四乙酸（EDTA）血浆中的补体成分C3和C4水平进行了测定，并对23对母婴血浆进行了检测。同时还测定了这些配对样本中的免疫球蛋白G、A和M浓度。此外，对伊洛林501名表面健康居民（年龄1至84岁，n = 313）及其郊区社区绍（年龄11至80岁，n = 188）的血清免疫球蛋白G、A和M水平进行了定量分析。总体而言，C3和C4值在性别上无显著差异，但这些值随年龄稳步上升。脐血血浆中C3和C4水平较高，分别占成人水平的73%和88%。这些补体成分的母体水平高于（P < 0.02）年龄相仿的非孕女性。母婴样本中获得的免疫球蛋白G值与尼日利亚其他中心先前报告的数据相当。23份脐血样本中，只有1份IgA和2份IgM样本显示可检测到这些免疫球蛋白。与尼日利亚埃努古和扎里亚报告的数据相比，伊洛林获得的免疫球蛋白平均浓度在IgG方面相似，IgA和IgM较低；而在绍，IgG较高，IgA和IgM较低。绍的IgG平均水平显著高于伊洛林，但IgA和IgM水平与伊洛林相当。总体而言，IgG和IgA浓度分别在31至40岁和41至50岁年龄组之前逐渐上升，然后下降。（摘要截选至250字）
