• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

诱导人对小鼠移植物抗宿主病的外周血白细胞移植物可排斥同种异体人皮肤移植物。

Peripheral blood leukocyte grafts that induce human to mouse graft-vs.-host disease reject allogeneic human skin grafts.

作者信息

Huppes W, Hoffmann-Fezer G

机构信息

Division of Health Research, Netherlands Organization for Applied Research (TNO), Rijswijk, The Netherlands.

出版信息

Am J Pathol. 1995 Dec;147(6):1708-14.

PMID:7495295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1869952/
Abstract

Allogeneic graft-versus-host disease is characterized by skin, gut, and bile duct destruction by relatively few donor type lymphocytes. In contrast, we can now show that human-to-mouse xenogeneic graft-versus-host disease is characterized by vasculitis and tumor-like infiltrations of the murine lymphohemopoietic organs with many human CD25+, HLA-DR+, CD4+ lymphoblasts. Using the technique of serial transplantation, it appears that at least 90% of the human lymphoblasts were unreactive to murine tissues. It is demonstrated consistently that the donor type lymphoblasts induced typical allogeneic rejection of distantly located full thickness human unmatched fetal skin grafts. The fact that the human grafts show primary immune responses in vivo indicates that the graft-versus-host disease murine model may be suitable for vaccination studies.

摘要

异基因移植物抗宿主病的特征是相对较少的供体型淋巴细胞对皮肤、肠道和胆管造成破坏。相比之下，我们现在可以证明，人对小鼠的异种移植物抗宿主病的特征是小鼠淋巴造血器官出现血管炎和肿瘤样浸润，其中有许多人CD25+、HLA-DR+、CD4+淋巴母细胞。使用连续移植技术，似乎至少90%的人淋巴母细胞对小鼠组织无反应。一致证明，供体型淋巴母细胞可诱导远处全层人不匹配胎儿皮肤移植物发生典型的同种异体排斥反应。人移植物在体内表现出初次免疫反应这一事实表明，移植物抗宿主病小鼠模型可能适用于疫苗接种研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ba/1869952/6511aad758d3/amjpathol00048-0195-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ba/1869952/787519f470af/amjpathol00048-0195-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ba/1869952/6511aad758d3/amjpathol00048-0195-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ba/1869952/787519f470af/amjpathol00048-0195-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85ba/1869952/6511aad758d3/amjpathol00048-0195-b.jpg

相似文献

1
Peripheral blood leukocyte grafts that induce human to mouse graft-vs.-host disease reject allogeneic human skin grafts.诱导人对小鼠移植物抗宿主病的外周血白细胞移植物可排斥同种异体人皮肤移植物。
Am J Pathol. 1995 Dec;147(6):1708-14.
2
A model of human anti-T-cell monoclonal antibody therapy in SCID mice engrafted with human peripheral blood lymphocytes.在移植了人外周血淋巴细胞的重症联合免疫缺陷（SCID）小鼠中进行人抗T细胞单克隆抗体治疗的模型。
Clin Transplant. 1997 Oct;11(5 Pt 2):522-8.
3
SCID mouse as a model for transplantation studies.重症联合免疫缺陷小鼠作为移植研究的模型。
J Surg Res. 1996 Sep;65(1):34-41. doi: 10.1006/jsre.1996.0340.
4
T lymphocytes determine the development of xeno GVHD and of human hemopoiesis in NOD/SCID mice following human umbilical cord blood transplantation.T淋巴细胞决定了人脐血移植后NOD/SCID小鼠中异种移植物抗宿主病（xeno GVHD）的发展以及人类造血作用的发展。
Stem Cells. 1998;16 Suppl 1:205-17. doi: 10.1002/stem.5530160825.
5
Human myeloid dendritic cells transduced with an adenoviral interleukin-10 gene construct inhibit human skin graft rejection in humanized NOD-scid chimeric mice.用腺病毒白细胞介素-10基因构建体转导的人髓样树突状细胞可抑制人源化NOD-scid嵌合小鼠中的人皮肤移植排斥反应。
Gene Ther. 2001 Aug;8(16):1224-33. doi: 10.1038/sj.gt.3301513.
6
Simultaneous protection against allograft rejection and graft-versus-host disease after total lymphoid irradiation: role of natural killer T cells.全身淋巴照射后对同种异体移植排斥反应和移植物抗宿主病的同时保护作用：自然杀伤T细胞的作用
Transplantation. 2008 Feb 27;85(4):607-14. doi: 10.1097/TP.0b013e31816361ce.
7
Facilitation of parental-strain marrow engraftment by T cells of neonatally-tolerant mice.新生期耐受小鼠的T细胞促进亲本品系骨髓移植
Biol Blood Marrow Transplant. 1997 Dec;3(6):294-303.
8
Role of immunoregulatory donor T cells in suppression of graft-versus-host disease following donor leukocyte infusion therapy.免疫调节性供体T细胞在供体白细胞输注治疗后抑制移植物抗宿主病中的作用。
J Immunol. 1999 Dec 15;163(12):6479-87.
9
Clinical relevance of recipient leukocyte infusion as antitumor therapy following nonmyeloablative allogeneic hematopoietic cell transplantation.非清髓性异基因造血细胞移植后，输注受者白细胞作为抗肿瘤治疗的临床相关性。
Exp Hematol. 2006 Sep;34(9):1271-7. doi: 10.1016/j.exphem.2006.04.022.
10
Involvement of the programmed death-1/programmed death-1 ligand pathway in CD4+CD25+ regulatory T-cell activity to suppress alloimmune responses.程序性死亡-1/程序性死亡-1配体途径参与CD4+CD25+调节性T细胞抑制同种免疫反应的活性。
Transplantation. 2007 Mar 27;83(6):774-82. doi: 10.1097/01.tp.0000256293.90270.e8.

引用本文的文献

1
Update of humanized animal disease models in studying Graft-versus-host disease.研究移植物抗宿主病的人源化动物疾病模型的更新。
Hum Vaccin Immunother. 2018;14(11):2618-2623. doi: 10.1080/21645515.2018.1512454. Epub 2018 Sep 5.
2
Human allograft rejection in humanized mice: a historical perspective.人源化小鼠中的同种异体移植物排斥反应：历史视角。
Cell Mol Immunol. 2012 May;9(3):225-31. doi: 10.1038/cmi.2011.64. Epub 2012 Feb 13.
3
Dermal microvascular injury in the human peripheral blood lymphocyte reconstituted-severe combined immunodeficient (HuPBL-SCID) mouse/skin allograft model is T cell mediated and inhibited by a combination of cyclosporine and rapamycin.

本文引用的文献

1
The fate of human peripheral blood lymphocytes after transplantation into SCID mice.人类外周血淋巴细胞移植到重症联合免疫缺陷小鼠后的命运。
Eur J Immunol. 1993 May;23(5):1023-8. doi: 10.1002/eji.1830230506.
2
Resistance to human immunodeficiency virus 1 infection of SCID mice reconstituted with peripheral blood leukocytes from donors vaccinated with vaccinia gp160 and recombinant gp160.用痘苗病毒gp160和重组gp160免疫接种的供体的外周血白细胞重建的SCID小鼠对人免疫缺陷病毒1感染的抗性。
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2443-7. doi: 10.1073/pnas.90.6.2443.
3
Immunohistology and immunocytology of human T-cell chimerism and graft-versus-host disease in SCID mice.
在人外周血淋巴细胞重建的严重联合免疫缺陷（HuPBL-SCID）小鼠/皮肤同种异体移植模型中，皮肤微血管损伤是由T细胞介导的，并受到环孢素和雷帕霉素联合用药的抑制。
Am J Pathol. 1998 Aug;153(2):627-38. doi: 10.1016/S0002-9440(10)65604-0.
4
Experimental production and modulation of human cytotoxic dermatitis in human-murine chimeras.人鼠嵌合体中人类细胞毒性皮炎的实验性产生与调控
Am J Pathol. 1997 Feb;150(2):631-9.
SCID小鼠中人T细胞嵌合现象与移植物抗宿主病的免疫组织学和免疫细胞学研究
Blood. 1993 Jun 15;81(12):3440-8.
4
Cytokine dependence of human to mouse graft-versus-host disease.人源至小鼠移植物抗宿主病的细胞因子依赖性
Scand J Immunol. 1994 Jul;40(1):26-36. doi: 10.1111/j.1365-3083.1994.tb03429.x.
5
Transfer of a functional human immune system to mice with severe combined immunodeficiency.将功能性人类免疫系统转移至重症联合免疫缺陷小鼠体内。
Nature. 1988 Sep 15;335(6187):256-9. doi: 10.1038/335256a0.
6
scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.小鼠中的严重联合免疫缺陷（scid）突变使其对电离辐射过敏，且DNA双链断裂修复存在缺陷。
Proc Natl Acad Sci U S A. 1991 Feb 15;88(4):1394-7. doi: 10.1073/pnas.88.4.1394.
7
The scid mouse: mutation in a DNA repair gene creates recipients useful for studies on stem cells, lymphocyte development and graft-versus-host disease.重度联合免疫缺陷小鼠：DNA修复基因中的突变产生了可用于干细胞、淋巴细胞发育及移植物抗宿主病研究的受体。
Immunol Rev. 1991 Dec;124:63-74. doi: 10.1111/j.1600-065x.1991.tb00616.x.
8
Acute human vs. mouse graft vs. host disease in normal and immunodeficient mice.正常及免疫缺陷小鼠中的急性人源对小鼠移植物抗宿主病
Eur J Immunol. 1992 Jan;22(1):197-206. doi: 10.1002/eji.1830220129.
9
Phenotypic and functional studies of human peripheral blood lymphocytes engrafted in scid mice.移植到重度联合免疫缺陷小鼠体内的人外周血淋巴细胞的表型和功能研究。
Immunol Rev. 1991 Dec;124:97-111. doi: 10.1111/j.1600-065x.1991.tb00618.x.
10
hu-PBL-SCID mice: a model for human immune function, AIDS, and lymphomagenesis.人外周血淋巴细胞-重症联合免疫缺陷小鼠：人类免疫功能、艾滋病及淋巴瘤发生的模型
Immunol Rev. 1991 Dec;124:139-64. doi: 10.1111/j.1600-065x.1991.tb00620.x.