Lavin J H, Read N W
Centre for Human Nutrition, Northern General Hospital, Sheffield, UK.
Appetite. 1995 Aug;25(1):89-96. doi: 10.1006/appe.1995.0043.
To investigate the relative potency of short-term control mechanisms for carbohydrate satiety, ten fasted, healthy male volunteers consumed a 250-ml, 30% glucose drink with and without the addition of guar gum (2%). Gastric emptying, hunger and fullness ratings and blood glucose and insulin levels were monitored over the following 3 h and energy intake was recorded from a test meal given 3.5 h after the drinks. The addition of the guar gum to the glucose drink lowered both postprandial glucose and insulin levels over the following 2 h. This was associated with a reduction in the ratings for hunger and desire to eat and an increase in ratings for fullness and satiety, but energy intake from the test meal was unchanged. There was no difference between values for the half time for gastric emptying for the two drinks. The short-term increase in satiety and decrease in hunger seen when glucose absorption was slowed with guar gum is unlikely to be explained by the reduction in postprandial glycaemia or differences in gastric emptying, and instead may implicate increased contact of the carbohydrate with receptors in the small intestine and consequent enhanced release of putative satiety peptides.
为了研究碳水化合物饱腹感短期控制机制的相对效力，十名空腹的健康男性志愿者饮用了250毫升、30%的葡萄糖饮料，其中一组添加了瓜尔胶（2%），另一组未添加。在接下来的3小时内监测胃排空、饥饿和饱腹感评分以及血糖和胰岛素水平，并记录在饮用饮料3.5小时后给予的测试餐中的能量摄入量。在葡萄糖饮料中添加瓜尔胶在接下来的2小时内降低了餐后血糖和胰岛素水平。这与饥饿和进食欲望评分的降低以及饱腹感和饱足感评分的增加有关，但测试餐的能量摄入量没有变化。两种饮料的胃排空半衰期值没有差异。当用瓜尔胶减缓葡萄糖吸收时，饱腹感短期增加和饥饿感降低不太可能通过餐后血糖降低或胃排空差异来解释，相反，可能意味着碳水化合物与小肠中的受体接触增加，从而增强了假定饱腹感肽的释放。
