Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Frederiksberg, Denmark.
Obesity (Silver Spring). 2012 Sep;20(9):1851-8. doi: 10.1038/oby.2011.232. Epub 2011 Jul 21.
Viscous dietary fibers such as sodium alginate extracted from brown seaweed have received much attention lately for their potential role in energy regulation through the inhibition of energy intake and increase of satiety feelings. The aim of our study was to investigate the effect on postprandial satiety feelings, energy intake, and gastric emptying rate (GER), by the paracetamol method, of two different volumes of an alginate-based preload in normal-weight subjects. In a four-way placebo-controlled, double-blind, crossover trial, 20 subjects (age: 25.9 ± 3.4 years; BMI: 23.5 ± 1.7 kg/m(2)) were randomly assigned to receive a 3% preload concentration of either low volume (LV; 9.9 g alginate in 330 ml) or high volume (HV; 15.0 g alginate in 500 ml) alginate-based beverage, or an iso-volume placebo beverage. The preloads were ingested 30 min before a fixed breakfast and again before an ad libitum lunch. Consumption of LV-alginate preload induced a significantly lower (8.0%) energy intake than the placebo beverage (P = 0.040) at the following lunch meal, without differences in satiety feelings or paracetamol concentrations. The HV alginate significantly increased satiety feelings (P = 0.038), reduced hunger (P = 0.042) and the feeling of prospective food consumption (P = 0.027), and reduced area under the curve (iAUC) paracetamol concentrations compared to the placebo (P = 0.05). However, only a 5.5% reduction in energy intake was observed for HV alginate (P = 0.20). Although they are somewhat contradictory, our results suggest that alginate consumption does affect satiety feelings and energy intake. However, further investigation on the volume of alginate administered is needed before inferring that this fiber has a possible role in short-term energy regulation.
粘性膳食纤维，如从褐藻中提取的藻酸钠，因其在抑制能量摄入和增加饱腹感方面的潜在作用，最近受到了广泛关注。本研究旨在通过对乙酰氨基酚法，研究两种不同体积的藻酸盐负荷对正常体重受试者餐后饱腹感、能量摄入和胃排空率（GER）的影响。在一项四向安慰剂对照、双盲、交叉试验中，20 名受试者（年龄：25.9 ± 3.4 岁；BMI：23.5 ± 1.7 kg/m²）随机分为三组，分别给予低体积（LV；330 ml 中含 9.9 g 藻酸盐）、高体积（HV；500 ml 中含 15.0 g 藻酸盐）或等体积安慰剂藻酸盐负荷液。负荷液在固定早餐前 30 分钟和自由午餐前再次摄入。与安慰剂饮料相比，LV-藻酸盐负荷液可显著降低（8.0%）随后午餐的能量摄入（P = 0.040），但对饱腹感或对乙酰氨基酚浓度无差异。与安慰剂相比，HV 藻酸盐可显著增加饱腹感（P = 0.038）、减少饥饿感（P = 0.042）和预期食物摄入量的感觉（P = 0.027），并降低对乙酰氨基酚浓度的曲线下面积（iAUC）（P = 0.05）。然而，HV 藻酸盐的能量摄入仅减少了 5.5%（P = 0.20）。尽管结果有些矛盾，但我们的研究结果表明，藻酸盐的摄入确实会影响饱腹感和能量摄入。然而，在推断这种纤维可能在短期能量调节中发挥作用之前，还需要进一步研究给予的藻酸盐体积。
