Cantarelli M J, Carvalho A C, de Almeida D R, Azevedo J E, Smith A C, Campos Filho O, Martinez Filho E E
Escola Paulista de Medicina, UNIFESP.
Arq Bras Cardiol. 1995 Apr;64(4):335-9.
To evaluate the acute hemodynamic effects of ibopamine (IBO), captopril (CAP) and placebo (PLA) in patients with severe congestive heart failure at rest.
Twelve male patients in sinus rhythm with dilated cardiomyopathy and NYHA class IV were studied with Swan-Ganz hemodynamics. Drugs were given in a blinded fashion. Rest, 30 min and every hour for 5 h measurements were made after oral ingestion of 100 mg IBO, 25 mg CAP or PLA. Prior to the study, patients were on diuretics as the only medication for at least 48 h. Comparisons were made with analysis of variance of repeated measurements and Duncan's multiple comparisons procedure.
Significant increase in cardiac index and stroke volume index and reduction in systemic vascular resistance were observed with IBO and CAP for 2 h after ingestion. IBO however increased right and left filling pressures in the first hour after its administration. Ventricular tachycardia occurred in 2 patients 1 h after IBO administration.
Both IBO and CAP improved hemodynamic parameters in the first two hours after oral ingestion in patients with dilated cardiomyopathy in class IV.
评估异波帕胺（IBO）、卡托普利（CAP）和安慰剂（PLA）对重度充血性心力衰竭患者静息状态下急性血流动力学的影响。
对12例窦性心律、扩张型心肌病且纽约心脏病协会（NYHA）心功能IV级的男性患者进行了Swan - Ganz血流动力学研究。药物以盲法给予。口服100 mg IBO、25 mg CAP或PLA后，在静息状态下、30分钟时以及之后5小时内每小时进行测量。研究前，患者至少48小时仅使用利尿剂作为唯一药物。采用重复测量方差分析和邓肯多重比较程序进行比较。
摄入IBO和CAP后2小时，观察到心脏指数和每搏量指数显著增加，全身血管阻力降低。然而，IBO给药后第1小时右心房和左心房充盈压升高。2例患者在IBO给药后1小时出现室性心动过速。
对于IV级扩张型心肌病患者，口服IBO和CAP后最初两小时内均可改善血流动力学参数。
