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五元环激动剂与毒蕈碱受体:20年回顾

Pentatomic cyclic agonists and muscarinic receptors: a 20 years review.

作者信息

Angeli P

机构信息

Dipartimento di Scienze Chimiche, Università di Camerino, Italy.

出版信息

Farmaco. 1995 Sep;50(9):565-77.

PMID:7495467
Abstract

The results of 20 years of structure-activity relationship (SAR) studies of pentatomic cyclic agonists on muscarinic receptors are reported and commented. Our results are compared with the findings obtained from quantitative structure-activity relationship (QSAR) studies and from those of molecular biology. The results from all three approaches point in the same direction and should help in the future design of new muscarinic agonists.

摘要

本文报道并评论了对五元环毒蕈碱受体激动剂进行的20年构效关系(SAR)研究结果。我们将自己的结果与定量构效关系(QSAR)研究以及分子生物学研究的结果进行了比较。这三种方法所得结果指向同一方向,应有助于未来新型毒蕈碱激动剂的设计。

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