Agre P, Brown D, Nielsen S
Department of Biological Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2185, USA.
Curr Opin Cell Biol. 1995 Aug;7(4):472-83. doi: 10.1016/0955-0674(95)80003-4.
The long-standing biophysical question of how water crosses plasma membranes has been answered by the recent discovery of the aquaporins. Identification of this large family of membrane water-transport proteins has generated new questions about the physiological functions, tissue distributions, and regulatory mechanisms of individual aquaporins. The fast pace of developments in this field has also resulted in major discrepancies in published reports which warrant resolution.
水如何穿过质膜这一长期存在的生物物理问题已因水通道蛋白的最新发现而得到解答。对这个膜水转运蛋白大家族的鉴定引发了关于单个水通道蛋白的生理功能、组织分布和调节机制的新问题。该领域快速的发展步伐也导致已发表报告中出现重大差异，需要加以解决。
