Mechanisms of iron uptake by mammalian cells.

On the basis of the discussion in this paper, the process of transferrin and iron (transferrin-bound iron and non transferrin-bound iron) uptake and transferrin release by reticulocytes are summarized diagrammatically. Although we were able to outline the pathways shown in the figure, there is still a long way to go before we achieve total understanding of the mechanisms of iron uptake. In addition, many important questions need to be answered. For example: what is the nature and properties of the iron carrier on the membrane? What is the relationship between the iron carrier and transferrin receptor? Is the iron carrier system in membranes of cells from different tissues similar or different? And how does iron cross the membrane of the endosomes after it is released from transferrin? All of these questions merit further investigation.