School of Pharmacy, Shaanxi University of Chinese Medicine, Xi'an, 712046, People's Republic of China.
State Key Laboratory of Research & Development of Characteristic Qin Medicine Resources (Cultivation), Shaanxi University of Chinese Medicine, Xi'an, 712046, People's Republic of China.
Int J Nanomedicine. 2023 Jul 28;18:4275-4311. doi: 10.2147/IJN.S410688. eCollection 2023.
Breast cancer (BC) is the most prevalent type of cancer in the world and the main reason women die from cancer. Due to the significant side effects of conventional treatments such as chemotherapy and radiotherapy, the search for supplemental and alternative natural drugs with lower toxicity and side effects is of interest to researchers. Curcumin (CUR) is a natural polyphenol extracted from turmeric. Numerous studies have demonstrated that CUR is an effective anticancer drug that works by modifying different intracellular signaling pathways. CUR's therapeutic utility is severely constrained by its short half-life in vivo, low water solubility, poor stability, quick metabolism, low oral bioavailability, and potential for gastrointestinal discomfort with high oral doses. One of the most practical solutions to the aforementioned issues is the development of targeted drug delivery systems (TDDSs) based on nanomaterials. To improve drug targeting and efficacy and to serve as a reference for the development and use of CUR TDDSs in the clinical setting, this review describes the physicochemical properties and bioavailability of CUR and its mechanism of action on BC, with emphasis on recent studies on TDDSs for BC in combination with CUR, including passive TDDSs, active TDDSs and physicochemical TDDSs.
乳腺癌（BC）是世界上最常见的癌症类型，也是女性癌症死亡的主要原因。由于化疗和放疗等传统治疗方法的副作用较大，因此研究人员对具有较低毒性和副作用的补充和替代天然药物的寻找很感兴趣。姜黄素（CUR）是从姜黄中提取的天然多酚。大量研究表明，CUR 是一种有效的抗癌药物，通过调节不同的细胞内信号通路发挥作用。CUR 的治疗用途受到其体内半衰期短、水溶性低、稳定性差、代谢快、口服生物利用度低以及大剂量口服时可能引起胃肠道不适等问题的严重限制。解决上述问题最实用的方法之一是基于纳米材料开发靶向药物传递系统（TDDS）。为了提高药物靶向性和疗效，并为 CUR TDDS 在临床环境中的开发和应用提供参考，本综述描述了 CUR 的理化性质和生物利用度及其对 BC 的作用机制，重点介绍了近年来结合 CUR 用于 BC 的 TDDS 的研究，包括被动 TDDS、主动 TDDS 和物理化学 TDDS。
