Inhibitor development in haemophiliacs: theoretical background and clinical aspects.

The development of factor VIII inhibitors is one of the most serious complications of repeated transfusions in haemophilia patients, but it is not clear why the complication develops only in some haemophiliacs. This paper discusses the nature of FVIII inhibitors, their occurrence and detection, and outlines treatment procedures for haemophilia patients who show FVIII inhibitors.