Sultan Y
Centre de l'Accueil et de Traitement des Hemophiles, Hopital Chochin, Paris, France.
Blood Coagul Fibrinolysis. 1995 Jul;6 Suppl 2:S80-1. doi: 10.1097/00001721-199506002-00016.
Some factor VIII concentrates cause downregulation of the immune system in HIV-positive haemophilia patients. This effect appears to be related to the purity of the concentrate, but not to its method of preparation. The optimum purity for preventing downregulation is not known at present.
一些凝血因子VIII浓缩剂会导致HIV阳性血友病患者的免疫系统下调。这种效应似乎与浓缩剂的纯度有关,而与其制备方法无关。目前尚不清楚预防下调的最佳纯度。