Sultan Y
Centre de l'Accueil et de Traitement des Hemophiles, Hopital Chochin, Paris, France.
Blood Coagul Fibrinolysis. 1995 Jul;6 Suppl 2:S80-1. doi: 10.1097/00001721-199506002-00016.
Some factor VIII concentrates cause downregulation of the immune system in HIV-positive haemophilia patients. This effect appears to be related to the purity of the concentrate, but not to its method of preparation. The optimum purity for preventing downregulation is not known at present.