van Leeuwen F, Nusse R
Howard Hughes Medical Institute, Department of Developmental Biology, Beckman Center, Stanford University, Medical Center, CA 94305-5428, USA.
Semin Cancer Biol. 1995 Jun;6(3):127-33. doi: 10.1006/scbi.1995.0018.
In this short review, we will give an overview of the various genes that can be activated by insertion of proviral DNA of the mouse mammary tumor virus during the formation of mammary cancer. These genes fall within three families: Wnt genes, FGF genes and Notch-related genes. We will summarize our current understanding of the roles of these genes in tumorigenesis and in normal development, and the mechanisms of action of their gene products. Finally, we will give some examples of cooperation between these genes in various biological settings.
在这篇简短的综述中，我们将概述在乳腺癌形成过程中，可被小鼠乳腺肿瘤病毒前病毒DNA插入激活的各种基因。这些基因分属三个家族：Wnt基因、FGF基因和Notch相关基因。我们将总结目前对这些基因在肿瘤发生和正常发育中的作用，以及其基因产物作用机制的理解。最后，我们将列举这些基因在各种生物学背景下协同作用的一些例子。
