周期性血小板减少症和血小板增多症中白细胞介素-6与血小板计数的同步波动。

Synchronous fluctuation of interleukin-6 and platelet count in cyclic thrombocytopenia and thrombocytosis.

作者信息

Kuyama J, Take H, Matsumoto S, Nakajima T, Sugase T, Hata A, Hanada M, Nakagawa K

机构信息

Department of Internal Medicine, Toyonaka Municipal Hospital.

出版信息

Intern Med. 1995 Jul;34(7):636-9. doi: 10.2169/internalmedicine.34.636.

DOI:10.2169/internalmedicine.34.636

PMID:7496073

Abstract

We describe a case of cyclic thrombocytopenia and thrombocytosis, whose cytokine levels, granulocyte-macrophage colony stimulating factor (GM-CSF) and interleukin-6 (IL-6) in plasma, fluctuated in synchrony with platelet count. The levels of the two cytokines correlated significantly with the platelet count for 11 observations over an 8-month period (r = 0.79, p < 0.01 for GM-CSF and r = 0.87, p < 0.001 for IL-6). No inverse relationship between platelet-associated immunoglobulin G (PAIgG) and platelet count was observed (r = 0.39, p > 0.20). These findings suggest that the fluctuation of platelet count in this case may result from an aberration of the cytokine network regulating megakaryopoiesis and platelet formation.

摘要

我们描述了一例周期性血小板减少和血小板增多症病例，其血浆中的细胞因子水平，即粒细胞-巨噬细胞集落刺激因子（GM-CSF）和白细胞介素-6（IL-6），与血小板计数同步波动。在8个月的时间里，对11次观察结果进行分析，这两种细胞因子的水平与血小板计数显著相关（GM-CSF的r = 0.79，p < 0.01；IL-6的r = 0.87，p < 0.001）。未观察到血小板相关免疫球蛋白G（PAIgG）与血小板计数之间存在负相关关系（r = 0.39，p > 0.20）。这些发现表明，该病例中血小板计数的波动可能是由于调节巨核细胞生成和血小板形成的细胞因子网络异常所致。