Kamiya Y, Horikoshi T, Takagi H, Okada S, Hashimoto K, Kido C, Takehara K, Nagamine T, Sekiguchi T, Mori M
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi.
Intern Med. 1995 Jul;34(7):679-82. doi: 10.2169/internalmedicine.34.679.
A 37-year-old Japanese man was admitted with delirium and hyperammonemia. He was diagnosed as having type II citrullinemia because of an elevated citrulline level on amino acid analysis and very low hepatic argininosuccinate synthetase activity. He also showed a low neutrophil count and a low serum level of granulocyte colony-stimulating factor. Reduced production of this cytokine and/or impairment of its feedback regulation by the neutrophil count may have played a role in the neutropenia of this patient.
一名37岁的日本男性因谵妄和高氨血症入院。由于氨基酸分析显示瓜氨酸水平升高且肝脏精氨琥珀酸合成酶活性极低，他被诊断为II型瓜氨酸血症。他还表现出中性粒细胞计数低和血清粒细胞集落刺激因子水平低。这种细胞因子产生减少和/或其受中性粒细胞计数的反馈调节受损可能在该患者的中性粒细胞减少中起了作用。
