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低溶血血液吸引器在手术过程中可保存血液。

A low-hemolysis blood aspirator conserves blood during surgery.

作者信息

Clague C T, Blackshear P L

机构信息

Biomedical Engineering Graduate Program, University of Minnesota, Minneapolis, USA.

出版信息

Biomed Instrum Technol. 1995 Sep-Oct;29(5):419-24.

PMID:7496409
Abstract

Blood damage caused by traditional vacuum-operated suction tubes, particularly when air is aspirated along with the blood, usually exceeds damage from all other components. In addition to platelet injury, there is a high degree of hemolysis, which leads to high plasma hemoglobin levels and reduces the number of red blood cells available for reinfusion during cases of blood conservation, such as autologous transfusion and cardiac bypass. This work was undertaken to minimize hemolysis, and the accompanying platelet destruction, during aspiration, with the design of a jet-driven aspirator that separates and removes air from blood immediately within the suction tip. The jet-driven aspirator can suction blood at a range of rates from 100 to at least 700 ml/min, separates and removes 80-100% of aspirated air, operates at any orientation, and generates subatmospheric pressures on the order of only 1 inch H2O. In-vitro hemolysis testing showed a significant reduction in average plasma hemoglobin release, from 19.4 mg/dl to 1.8 mg/dl, when air was removed during blood aspiration. In comparative testing with a conventional vacuum suction tube, the jet-driven aspirator showed significantly less hemolysis than the conventional aspirator at comparable rates of air and blood aspiration.

摘要

传统的真空操作吸引管造成的血液损伤,尤其是当空气与血液一起被抽吸时,通常超过所有其他组件造成的损伤。除了血小板损伤外,还存在高度的溶血现象,这会导致血浆血红蛋白水平升高,并减少在诸如自体输血和心脏搭桥等血液保存情况下可用于回输的红细胞数量。这项工作旨在通过设计一种喷射驱动的吸引器来尽量减少抽吸过程中的溶血以及随之而来的血小板破坏,该吸引器能在吸引尖端立即将空气从血液中分离并去除。喷射驱动的吸引器能够以100至至少700毫升/分钟的一系列速率抽吸血液,分离并去除80 - 100%的抽吸空气,可在任何方向操作,并且产生仅约1英寸水柱的负压。体外溶血测试表明,在血液抽吸过程中去除空气时,平均血浆血红蛋白释放量显著降低,从19.4毫克/分升降至1.8毫克/分升。在与传统真空吸引管的对比测试中,在空气和血液抽吸速率相当的情况下,喷射驱动的吸引器显示出的溶血程度明显低于传统吸引器。

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