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[高温避孕法用于男性避孕]

[Male contraception by hyperthermia].

作者信息

Bujan L, Mieusset R

机构信息

Centre de Stérilité et CECOS Midi-Pyrénées, CHU La Grave, Toulouse.

出版信息

Contracept Fertil Sex. 1995 Oct;23(10):611-4.

PMID:7496419
Abstract

Assessment of the contraceptive efficacy of a daily mild increase (1 degree C to 2 degree C) in testicular temperature during waking hours is reported in nine couples using two techniques of immobilization of the testes in a supra-scrotal position (close to the inguinal canal). With technique 1 (3 couples and 42 cycles), immobilization was achieved with a specific underwear; there was one undesired pregnancy from a man who stopped the heating for 3 weeks. With technique 2 (6 couples and 117 cycles), immobilization was achieved by adding a supplementary ring to the specific underwear; there was no pregnancy. Reversibility and safety were evaluated. These results suggest that a daily mild increase in testis temperature could be a potential contraceptive method for men.

摘要

报告了对9对夫妇进行的一项研究,该研究通过两种将睾丸固定在阴囊上方位置(靠近腹股沟管)的技术,评估清醒时睾丸温度每日轻度升高(1摄氏度至2摄氏度)的避孕效果。采用技术1(3对夫妇,42个周期)时,通过一种特殊内衣实现固定;有一名男子停止加热3周后发生了一次意外怀孕。采用技术2(6对夫妇,117个周期)时,通过在特殊内衣上添加一个辅助环实现固定;未发生怀孕。对可逆性和安全性进行了评估。这些结果表明,睾丸温度每日轻度升高可能是一种潜在的男性避孕方法。

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1
[Male contraception by hyperthermia].[高温避孕法用于男性避孕]
Contracept Fertil Sex. 1995 Oct;23(10):611-4.
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Int J Androl. 1994 Aug;17(4):186-91. doi: 10.1111/j.1365-2605.1994.tb01241.x.
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J Urol. 1998 Oct;160(4):1329-33.
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Mild testicular hyperthermia induces profound transitional spermatogenic suppression through increased germ cell apoptosis in adult cynomolgus monkeys (Macaca fascicularis).轻度睾丸高温通过增加成年食蟹猴(猕猴)生殖细胞凋亡诱导严重的生精过渡抑制。
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