Bancroft J, Malone N
MRC Reproductive Biology Unit, Royal Edinburgh Hospital.
Int J Impot Res. 1995 Jun;7(2):123-30.
One hundred and fifty-nine men with erectile dysfunction were assessed with Rigiscan monitoring of nocturnal penile tumescence (NPT) and response to intracavernosal injections (ICI) of papaverine or prostaglandin E1. A satisfactory NPT, suggestive of psychogenic causation, was recorded in 58%, whereas 15% had clearly impaired NPT. There was a significant association between presence of vascular disease, diabetes and impairment of NPT. For ICI, only 32% showed a satisfactory response, with 48% clearly impaired. Of the 92 men with satisfactory NPT, 40% HAD clearly impaired and 41% satisfactory ICI response. Of the 51 men with satisfactory ICI response, 8% had clearly impaired and 74.5% satisfactory NPT. There was no association between ICI response and history of vascular disease. We conclude that monitoring of NPT by Rigiscan, and without sleep monitoring, is a valuable diagnostic procedure. In contrast, because of the high proportion of false negative results. ICI monitoring is of very limited diagnostic value. The explanation for false negative ICI responses, however, could prove to be of considerable theoretical and clinical importance.
对159名勃起功能障碍男性进行了Rigiscan夜间阴茎勃起监测（NPT）以及对罂粟碱或前列腺素E1海绵体内注射（ICI）的反应评估。58%的患者记录到满意的NPT，提示心理性病因，而15%的患者NPT明显受损。血管疾病、糖尿病的存在与NPT受损之间存在显著关联。对于ICI，只有32%的患者显示出满意的反应，48%的患者明显受损。在92名NPT满意的男性中，40%的患者ICI反应明显受损，41%的患者ICI反应满意。在51名ICI反应满意的男性中，8%的患者NPT明显受损，74.5%的患者NPT满意。ICI反应与血管疾病史之间没有关联。我们得出结论，通过Rigiscan监测NPT且无需睡眠监测是一种有价值的诊断方法。相比之下，由于假阴性结果比例较高，ICI监测的诊断价值非常有限。然而，ICI假阴性反应的解释可能具有相当大的理论和临床重要性。
