Smith D H, Casey K, McIntosh T K
Division of Neurosurgery, University of Pennsylvania, Philadelphia 19104-6316, USA.
New Horiz. 1995 Aug;3(3):562-72.
An important feature of traumatic brain injury is that much of the ultimate damage appears to occur in a delayed or secondary fashion. Although the exact timing of these secondary sequelae has yet to be elucidated, recent experimental evidence suggests that an extended window of opportunity exists during which various forms of therapy appear to be efficacious. Moreover, new therapies have been developed which can be targeted at distinct pathophysiologic aspects of brain trauma. This article summarizes recent efforts to define secondary mechanisms of brain trauma and review the development of therapeutic strategies for reversing these deleterious events.
创伤性脑损伤的一个重要特征是，许多最终损伤似乎以延迟或继发性方式发生。尽管这些继发性后遗症的确切时间尚待阐明，但最近的实验证据表明，存在一个延长的机会窗口，在此期间各种形式的治疗似乎都是有效的。此外，已经开发出了针对脑外伤不同病理生理方面的新疗法。本文总结了近期在确定脑外伤继发性机制方面所做的努力，并回顾了逆转这些有害事件的治疗策略的发展情况。
