Henriksson A E, Edman A C, Held M, Wadström T
Department of Surgery, Sundsvall County Hospital, Sweden.
Eur J Gastroenterol Hepatol. 1995 Aug;7(8):769-71.
The prevalence of Helicobacter pylori in chronic peptic ulcer is well known. In this study the frequency of H. pylori infection was investigated in patients with acute bleeding peptic ulcer.
Prospective study in a district hospital.
Seventy consecutive patients with acute bleeding peptic ulcer.
Diagnosis was verified on admission by endoscopy, and healing was examined at follow-up. Previous history of ulcer disease, presence of dyspeptic symptoms and consumption of non-steroidal anti-inflammatory drugs were recorded.
H. pylori infection was detected by two serological tests in samples obtained on admission for the acute bleeding episode, and at follow-up 1-3 months later.
With a commercial latex immunoassay, 53% of the patients with gastric ulcer and 62% with duodenal ulcer were shown to possess H. pylori antibodies. In the other test, a standard enzyme-linked immunosorbent assay based on cell surface protein antigens of H. pylori with high sensitivity and specificity, 81% of gastric ulcer patients and 85% of duodenal ulcer patients were shown to have H. pylori antibodies.
The results indicate that H. pylori infection plays a major aetiological role in patients with acute bleeding peptic ulcer.
幽门螺杆菌在慢性消化性溃疡中的患病率众所周知。本研究调查了急性出血性消化性溃疡患者中幽门螺杆菌感染的频率。
在一家地区医院进行的前瞻性研究。
连续70例急性出血性消化性溃疡患者。
入院时通过内镜检查进行确诊，并在随访时检查愈合情况。记录溃疡病既往史、消化不良症状的存在情况以及非甾体抗炎药的使用情况。
在急性出血发作入院时及1 - 3个月后的随访时采集的样本中，通过两种血清学检测方法检测幽门螺杆菌感染情况。
采用商业乳胶免疫测定法，胃溃疡患者中有53%、十二指肠溃疡患者中有62%被检测出具有幽门螺杆菌抗体。在另一种检测中，即基于幽门螺杆菌细胞表面蛋白抗原的具有高灵敏度和特异性的标准酶联免疫吸附测定法，胃溃疡患者中有81%、十二指肠溃疡患者中有85%被检测出具有幽门螺杆菌抗体。
结果表明幽门螺杆菌感染在急性出血性消化性溃疡患者中起主要病因学作用。
