通过糖基氢膦酸二糖单体缩聚反应化学合成杜氏利什曼原虫磷酸聚糖。
The chemical synthesis of Leishmania donovani phosphoglycan via polycondensation of a glycobiosyl hydrogenphosphonate monomer.
作者信息
Nikolaev A V, Chudek J A, Ferguson M A
机构信息
Department of Biochemistry, University of Dundee, UK.
出版信息
Carbohydr Res. 1995 Aug 11;272(2):179-89. doi: 10.1016/0008-6215(95)00067-4.
PMID:7497476
Abstract
A polycondensation of 2,3,6-tri-O-benzoyl-4-O-(2,3,4-tri-O-benzoyl-beta-D-galactopyranosyl)-al pha-D-mannopyranosyl hydrogenphosphonate in the presence of trimethylacetyl chloride has been used to synthesize a linear poly[beta-D-galactopyranosyl-(1-->4)-alpha-D-mannopyranosyl phosphate] representing the phosphoglycan part of the lipophosphoglycan from Leishmania donovani.
摘要
在三甲基乙酰氯存在下，2,3,6-三-O-苯甲酰基-4-O-(2,3,4-三-O-苯甲酰基-β-D-吡喃半乳糖基)-α-D-吡喃甘露糖基氢膦酸酯发生缩聚反应，用于合成线性聚[β-D-吡喃半乳糖基-(1→4)-α-D-吡喃甘露糖基磷酸酯]，其代表杜氏利什曼原虫脂磷壁酸聚糖的磷酸聚糖部分。
Zotero 插件