Cho J, Lee Y, Lutzky J, Redpath L, Slater L
Department of Medicine and Radiation Oncology, University of California, Irvine 92717, USA.
Cancer Chemother Pharmacol. 1995;37(1-2):168-72. doi: 10.1007/BF00685645.
Although collateral sensitivity to gamma radiation has previously been described in multidrug-resistant tumor cell lines, we describe here a multidrug-resistant human T-cell acute lymphatic leukemia cell line, L100, which displayed increased sensitivity to both gamma radiation and cis-platinum. Cis-platinum cytotoxicity of parental L0 cells and L100 cells was enhanced, whereas radiation sensitivity of L0 and L100 cells was unaltered by glutathione depletion. These results indicate that disparate mechanisms are operative in the collateral sensitivity of L100 cells to gamma radiation and cis-platinum.
尽管之前在多药耐药肿瘤细胞系中已描述过对γ辐射的旁敏感性，但我们在此描述一种多药耐药的人T细胞急性淋巴细胞白血病细胞系L100，它对γ辐射和顺铂均表现出增强的敏感性。亲本L0细胞和L100细胞的顺铂细胞毒性增强，而L0和L100细胞的辐射敏感性不会因谷胱甘肽耗竭而改变。这些结果表明，不同的机制在L100细胞对γ辐射和顺铂的旁敏感性中起作用。
