Study of antibody-dependent cellular cytotoxicity (ADCC). I. Lymphocyte-mediated cytotoxicity by lymphocytes from healthy individuals.

Lymphocytes from 32 healthy blood donors were determined for their ability to mediate the cytolysis of antibody-coated target cells. As target cells a murine lymphoma cells the cytolysis of antibody-coated target cells. As target cells a murine lymphoma cells L1210 were used. Heat-inactivated rabbit anti-L1210 antiserum was source of antibody. ADCC activity was determined at following effector to target cell ratsio: 100:1, 30:1, 10:1, 3:1, 1:1. Lymphocytes of males had significantly higher activity as compared to female ones. The individual fluctuation among both groups was not statistically significant.