Lymphocytotoxic antibodies in sera of pregnant women: serological and clinical studies.

In order to obtain the sera for determining the histocompatibility antigens, 290 samples of blood collected from 278 women were examined for anti-HLA lymphocytotoxic antibodies. These were found in sera of 55 women (20%) and their specificity was identified in 15 samples. No effect of antepartum hemorrhage, premature births and abortions on the production of antibodies was found. The presence of cytotoxic antibodies had no effect on the course of pregnancy and timing of delivery.