McCauley P T, Robinson M, Daniel F B, Olson G R
Risk Reduction Engineering Laboratory U.S. EPA, Cincinnati, Ohio 45268, USA.
Drug Chem Toxicol. 1995 May-Aug;18(2-3):201-21. doi: 10.3109/01480549509014321.
Male and female Sprague-Dawley rats received 1,3-dichlorobenzene daily by corn oil gavage for 10 or 90 consecutive days. The 10-day study doses were 0, 37, 147, 368 and 735 mg/kg; the 90-day study doses were 0, 9, 37, 147 and 588 mg/kg. In the 10-day study, there was a significant depression of body weight in both sexes at 735 mg/kg. Liver weights were significantly increased in both sexes at 368 and 735 mg/kg. Serum cholesterol levels were significantly elevated in both sexes at 368 and 735 mg/kg. Histopathological evaluation revealed centrolobular hepatocellular degeneration at 368 mg/kg in males and 735 mg/kg in females. In the 90-day study, body weights were significantly depressed in both sexes at 588 mg/kg. Normalization of food and water consumption by final body weight indicated that at 588 mg/kg both sexes had increased food and water consumption relative to controls. Absolute and relative liver weights were significantly increased in both sexes at 147 and 588 mg/kg. Relative kidney weights were significantly higher in both sexes at 588 mg/kg and in males at 147 mg/kg. Serum cholesterol and calcium levels were significantly elevated over controls in females at 37, 147, and 588 mg/kg, and in males at all dose levels. Histopathological evaluation at 147 and/or 588 mg/kg demonstrated liver and thyroid lesions in both sexes, and pituitary and kidney lesions in males. A NOAEL was not firmly established.
将雄性和雌性斯普拉格-道利大鼠每天通过玉米油灌胃给予1,3-二氯苯，连续给药10天或90天。10天研究的剂量为0、37、147、368和735毫克/千克；90天研究的剂量为0、9、37、147和588毫克/千克。在10天研究中，735毫克/千克剂量组的两性体重均显著下降。368和735毫克/千克剂量组的两性肝脏重量均显著增加。368和735毫克/千克剂量组的两性血清胆固醇水平均显著升高。组织病理学评估显示，雄性368毫克/千克剂量组和雌性735毫克/千克剂量组出现小叶中心肝细胞变性。在90天研究中，588毫克/千克剂量组的两性体重均显著下降。按最终体重对食物和水消耗进行归一化处理表明，588毫克/千克剂量组的两性相对于对照组食物和水消耗增加。147和588毫克/千克剂量组的两性绝对和相对肝脏重量均显著增加。588毫克/千克剂量组的两性以及147毫克/千克剂量组的雄性相对肾脏重量显著更高。37、147和588毫克/千克剂量组的雌性以及所有剂量水平的雄性血清胆固醇和钙水平均显著高于对照组。147和/或588毫克/千克剂量组的组织病理学评估显示两性均有肝脏和甲状腺病变，雄性有垂体和肾脏病变。未明确确定无观察到有害作用水平（NOAEL）。
