van der Wielen R P, van Heereveld H A, de Groot C P, van Staveren W A
Department of Human Nutrition, Wageningen Agricultural University, The Netherlands.
Eur J Clin Nutr. 1995 Sep;49(9):665-74.
To assess the nutritional status of female elderly nursing home residents and to study the effect of dietary supplementation with a physiological dose of water-soluble vitamins.
Single-blind, randomised, placebo-controlled intervention trial. Daily consumed supplement consisted of fortified fruit juice containing 50 g carbohydrate and 50% of the daily dietary recommendations of water-soluble vitamins. Regular fruit juice was used as placebo. Dietary intake assessment at baseline. Fasting blood sample, anthropometric measurements and medical record at baseline and after 4 and 12 weeks of supplementation.
Three nursing homes within 40 km of the coordination centre (Department of Human Nutrition, Wageningen Agricultural University, the Netherlands).
Forty-two female nursing home residents aged 60 years and older, in relatively stable health condition, at least 3 months resident at baseline. In each nursing home, 14 subjects were randomly assigned to the supplement or control group.
Twelve weeks of supplementation.
Participants had a poor nutritional status. Dietary supplementation significantly improved the concentrations of thiamin pyrophosphate and pyridoxal 5'-phosphate, increased body weight and decreased serum homocysteine concentration in the supplement group. Plasma vitamin C levels were significantly increased in both supplement and control group.
Even in this heterogeneous population of female nursing home elderly it is possible to improve the nutritional status through dietary intervention with a physiological dose of water-soluble vitamins.
评估老年女性养老院居民的营养状况，并研究补充生理剂量水溶性维生素的饮食效果。
单盲、随机、安慰剂对照干预试验。每日食用的补充剂为强化果汁，含有50克碳水化合物和水溶性维生素每日膳食推荐量的50%。普通果汁用作安慰剂。在基线时进行饮食摄入量评估。在基线时以及补充4周和12周后采集空腹血样、进行人体测量并查看病历。
距离协调中心（荷兰瓦赫宁根农业大学人类营养系）40公里范围内的三家养老院。
42名60岁及以上的老年女性养老院居民，健康状况相对稳定，基线时至少已入住3个月。在每家养老院，14名受试者被随机分配到补充剂组或对照组。
为期12周的补充。
参与者营养状况较差。补充剂组中，膳食补充显著提高了硫胺素焦磷酸和磷酸吡哆醛的浓度，增加了体重并降低了血清同型半胱氨酸浓度。补充剂组和对照组的血浆维生素C水平均显著升高。
即使在这个老年女性养老院居民的异质性群体中，通过补充生理剂量的水溶性维生素进行饮食干预也有可能改善营养状况。
