Kyriakides Z S, Markianos M, Iliodromitis E K, Kremastinos D T
Athens General Hospital, Greece.
Eur Heart J. 1995 Jul;16(7):894-8. doi: 10.1093/oxfordjournals.eurheartj.a061021.
Endothelin-1 and cyclic guanosine monophosphate (c-GMP) peripheral vein plasma levels increase during coronary angioplasty, but the reason for this increase has not been elucidated. The purpose of this study was to investigate whether these changes are related to myocardial ischaemia, or to mechanical artery injury induced during the procedure. Thirty-two patients with stable angina pectoris and a single lesion were studied. They were aged 56 +/- 8 and were undergoing balloon angioplasty. Eight arteries were totally occluded and 24 were partially occluded. Blood samples were drawn from a peripheral vein after coronary artery engagement with the guiding catheter (baseline), after the first balloon inflation, immediately after the end of the procedure, and 4 h later. In the total occlusion group endothelin-1 increased by 7% (P ns), whereas in the partial occlusion group it increased by 45% after the procedure (P < 0.001). c-GMP in the partial occlusion group increased by 41% (P < 0.001) after the procedure whereas in the total occlusion group it increased by 5% (P ns). Thus, the increase in endothelin-1 and c-GMP peripheral vein plasma levels after coronary angioplasty is related to myocardial ischaemia rather than to mechanical artery injury.
冠状动脉血管成形术期间，内皮素 -1和环磷酸鸟苷（c - GMP）外周静脉血浆水平升高，但其升高原因尚未阐明。本研究的目的是调查这些变化是否与心肌缺血有关，还是与手术过程中引起的机械性动脉损伤有关。对32例患有稳定型心绞痛且仅有一处病变的患者进行了研究。他们的年龄为56±8岁，正在接受球囊血管成形术。8条动脉完全闭塞，24条动脉部分闭塞。在冠状动脉与引导导管接触后（基线）、首次球囊扩张后、手术结束后立即以及4小时后，从外周静脉采集血样。在完全闭塞组中，内皮素 -1升高了7%（P无统计学意义），而在部分闭塞组中，术后升高了45%（P < 0.001）。部分闭塞组术后c - GMP升高了41%（P < 0.001），而完全闭塞组升高了5%（P无统计学意义）。因此，冠状动脉血管成形术后内皮素 -1和c - GMP外周静脉血浆水平的升高与心肌缺血有关，而非与机械性动脉损伤有关。
