Włodarski K, Jakóbisiak M
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):671-3.
L-asparaginase pretreatment prior to sublethal whole body irradiation resulted in decrease of endogenous spleen colonies. This effect was abolished by the simultaneous addition of L-asparagine. L-asparaginase administered after sublethal irradiation did not reduce the number of spleen colonies. This result agrees with the suggestion that L-asparaginase inhibits the proliferation of undifferentiated but not of differentiated cells.
在亚致死性全身照射前进行L-天冬酰胺酶预处理可导致内源性脾集落数量减少。同时添加L-天冬酰胺可消除这种效应。亚致死性照射后给予L-天冬酰胺酶不会减少脾集落的数量。这一结果与L-天冬酰胺酶抑制未分化细胞而非分化细胞增殖的观点一致。
