Bartens W, Rader D J, Talley G, Brewer H B
Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Eur J Clin Invest. 1995 Sep;25(9):647-53. doi: 10.1111/j.1365-2362.1995.tb01980.x.
Lipoprotein (a) [Lp(a)] is an atherogenic lipoprotein which is similar in structure to, but metabolically distinct from, LDL. Factors modulating plasma Lp(a) concentrations are poorly understood. We hypothesized that patients with hyperlipidaemia have elevated Lp(a) levels and determined the phenotype, concentration and distribution of Lp(a) in a group of hyperlipidaemic patients (n = 107) compared with a control group (n = 128). Lp(a) concentrations were significantly increased in the hyperlipidaemic patients (mean, 34 +/- 4 mg dL-1; median, 19 mg dL-1) as compared with the controls (20 +/- 3 mg dL-1; 9 mg dL-1) (P < 0.01). Interestingly, after dividing the patients into one group with elevated cholesterol (> 200 mg dL-1) (n = 44) and another group with elevated triglycerides (> 200 mg dL-1) (n = 51) we found that Lp(a) concentrations were 2.3-fold higher in the high cholesterol patients (mean, 45 +/- 5; median, 41 mg dL-1) compared to the high triglyceride subjects (20 +/- 4; 8 mg dL-1) (P < 0.01). Furthermore, a negative correlation between triglyceride and Lp(a) plasma concentrations was found in patients exhibiting triglyceride levels > 300 mg dL-1 (r = -0.41, P = 0.04, n = 36) and with triglycerides > 400 mg dL-1 (r = -0.52, P = 0.03, n = 17). These data indicate that plasma Lp(a) concentrations are elevated in hyperlipidaemia if the patients have high cholesterol levels, whereas Lp(a) is normal to low in patients with elevated triglycerides.(ABSTRACT TRUNCATED AT 250 WORDS)
脂蛋白(a)[Lp(a)]是一种致动脉粥样硬化脂蛋白，其结构与低密度脂蛋白(LDL)相似，但代谢方式不同。目前对调节血浆Lp(a)浓度的因素了解甚少。我们推测高脂血症患者的Lp(a)水平升高，并比较了一组高脂血症患者(n = 107)与对照组(n = 128)的Lp(a)表型、浓度和分布。与对照组(20±3 mg/dL；9 mg/dL)相比，高脂血症患者的Lp(a)浓度显著升高(平均值为34±4 mg/dL；中位数为19 mg/dL)(P<0.01)。有趣的是，将患者分为胆固醇升高(>200 mg/dL)组(n = 44)和甘油三酯升高(>200 mg/dL)组(n = 51)后，我们发现高胆固醇患者的Lp(a)浓度(平均值为45±5；中位数为41 mg/dL)是高甘油三酯患者(20±4；8 mg/dL)的2.3倍(P<0.01)。此外，在甘油三酯水平>300 mg/dL(r = -0.41，P = 0.04，n = 36)和甘油三酯>400 mg/dL(r = -0.52，P = 0.03，n = 17)的患者中，发现甘油三酯与血浆Lp(a)浓度呈负相关。这些数据表明，如果高脂血症患者胆固醇水平高，则血浆Lp(a)浓度升高，而甘油三酯升高的患者Lp(a)水平正常至偏低。(摘要截选至250词)
