大鼠离体肾脏和麻醉大鼠中的肾上腺髓质素与降钙素基因相关肽：体内外效应

Adrenomedullin and calcitonin gene-related peptide in the rat isolated kidney and in the anaesthetised rat: in vitro and in vivo effects.

作者信息

Haynes J M, Cooper M E

机构信息

Department of Medicine, University of Melbourne, Repatriation General Hospital, Heidelberg West, Victoria, Australia.

出版信息

Eur J Pharmacol. 1995 Jun 23;280(1):91-4. doi: 10.1016/0014-2999(95)00230-i.

DOI:10.1016/0014-2999(95)00230-i

PMID:7498258

Abstract

The effects of adrenomedullin and calcitonin gene-related peptide (CGRP) were compared in the rat isolated perfused kidney and in the anaesthetised rat. Adrenomedullin and CGRP both elicited concentration-dependent vasodilator responses from perfused kidneys (adrenomedullin was less potent than CGRP). These responses were blocked by CGRP-(8-37) (1 microM). Adrenomedullin and CGRP elicited dose-dependent hypotension in anaesthetised rats (adrenomedullin was less potent than CGRP). The hypotensive responses to CGRP, but not those to adrenomedullin, were antagonized by CGRP-(8-37) (12 nmol/kg/min). These studies indicate that the in vivo response to adrenomedullin may be mediated through CGRP-(8-37) insensitive receptors.

摘要

在大鼠离体灌注肾和麻醉大鼠中比较了肾上腺髓质素和降钙素基因相关肽（CGRP）的作用。肾上腺髓质素和CGRP均可引起灌注肾的浓度依赖性血管舒张反应（肾上腺髓质素的效力低于CGRP）。这些反应被CGRP-（8-37）（1微摩尔）阻断。肾上腺髓质素和CGRP在麻醉大鼠中引起剂量依赖性低血压（肾上腺髓质素的效力低于CGRP）。CGRP-（8-37）（12纳摩尔/千克/分钟）可拮抗对CGRP的低血压反应，但不能拮抗对肾上腺髓质素的反应。这些研究表明，体内对肾上腺髓质素的反应可能通过对CGRP-（8-37）不敏感的受体介导。