大麻素通过选择性大麻素受体拮抗剂SR 141716A引发戒断反应。
Cannabinoid precipitated withdrawal by the selective cannabinoid receptor antagonist, SR 141716A.
作者信息
Aceto M D, Scates S M, Lowe J A, Martin B R
机构信息
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond 23298-0613, USA.
出版信息
Eur J Pharmacol. 1995 Aug 25;282(1-3):R1-2. doi: 10.1016/0014-2999(95)00447-s.
Precipitated withdrawal in rats chronically exposed to delta 9-tetrahydrocannabinol, the major psychoactive principle of the marijuana plant, was unequivocally demonstrated for the first time using a selective antagonist, SR 141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1(2,4- dichloro-phenyl)-4-methyl-1H-pyrazole carboxamide.HCl). This demonstration should provide a powerful stimulus for the systematic study of dependency on the psychoactive cannabinoids.
首次使用选择性拮抗剂SR 141716A（N-（哌啶-1-基）-5-（4-氯苯基）-1-（2,4-二氯苯基）-4-甲基-1H-吡唑甲酰胺盐酸盐）明确证实了长期暴露于大麻植物主要精神活性成分Δ9-四氢大麻酚的大鼠会出现戒断反应。这一证实应为系统研究对精神活性大麻素的依赖性提供有力推动。
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