银屑病中的自身免疫现象。
Autoimmune phenomena in psoriasis.
作者信息
Jabłońska S, Jarzabek-Chorzelska M, Maciejowska E, Chorzelski T, Rzesa G, Beutner E H
出版信息
Arch Immunol Ther Exp (Warsz). 1978;26(1-6):749-54.
The striatum corneum (SC) antibodies are present in all human sera as seen by indirect immunofluorescent (IF) staining. They appear to bind in vivo to the stratum corneum of psoriatic lesions. They fix complement in vitro in a two step complement IF test system using either anti C4 or anti C3 conjugates as indicators. IF tests with proper controls showed that the SC antigen in psoriatic scales is coated not only with IgG but in a majority of the lesions also with complement. These observations afford indirect evidence for the participation of SC antibodies and the ensuing fixation of complement in the development of psoriatic lesions.
通过间接免疫荧光（IF）染色可见，角质层（SC）抗体存在于所有人的血清中。它们似乎在体内与银屑病皮损的角质层结合。在使用抗C4或抗C3结合物作为指示剂的两步补体IF检测系统中，它们在体外可固定补体。采用适当对照的IF检测表明，银屑病鳞屑中的SC抗原不仅被IgG包被，而且在大多数皮损中还被补体包被。这些观察结果为SC抗体的参与以及随后补体的固定在银屑病皮损发展中的作用提供了间接证据。
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