Bernauer W
Department of Pharmacology, University of Freiburg, Germany.
Eur J Pharmacol. 1995 Sep 5;283(1-3):91-8. doi: 10.1016/0014-2999(95)00295-v.
In isolated perfused rat hearts the left coronary artery was occluded for 5 min, with subsequent reperfusion for 20 min. During the reperfusion severe tachyarrhythmias were observed, with ventricular fibrillation occurring in all hearts. Simultaneously, large amounts of adenosine and its degradation products inosine, hypoxanthine, xanthine and uric acid were released into the coronary perfusate. The antiarrhythmics quinidine, lidocaine and gallopamil significantly decreased the release. The effect of quinidine and lidocaine was linked with the antifibrillatory action of these drugs. Also the interruption of fibrillation immediately after its appearance by potassium chloride decreased the release of adenosine and its metabolites in a highly significant way. The effect of gallopamil on the release was independent of an antifibrillatory action. The findings indicate that different kinds of antiarrhythmic drugs can affect the release of nucleosides and oxypurines in hearts with ischaemia and reperfusion.
在离体灌注大鼠心脏中，左冠状动脉闭塞5分钟，随后再灌注20分钟。在再灌注期间，观察到严重的快速性心律失常，所有心脏均发生心室颤动。同时，大量腺苷及其降解产物肌苷、次黄嘌呤、黄嘌呤和尿酸释放到冠状动脉灌注液中。抗心律失常药物奎尼丁、利多卡因和加洛帕米显著减少了这种释放。奎尼丁和利多卡因的作用与这些药物的抗纤颤作用有关。同样，在心室颤动出现后立即用氯化钾中断颤动，可极显著地减少腺苷及其代谢产物的释放。加洛帕米对释放的影响与抗纤颤作用无关。这些发现表明，不同种类的抗心律失常药物可影响缺血再灌注心脏中核苷和氧嘌呤的释放。
